Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin Administration

Patients with rheumatoid arthritis (RA) are known to develop lymphoproliferative disorders (LPDs) during the course of illness, particularly in cases treated with methotrexate (MTX) for long periods. We describe a case of MTX-related Epstein-Barr-virus-(EBV-) associated LPD resembling Hodgkin's...

Descripción completa

Detalles Bibliográficos
Autores principales: Takemori, Nobuo, Kaneko, Hiroyuki, Nakamura, Masaya, Kojima, Masaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535817/
https://www.ncbi.nlm.nih.gov/pubmed/23316401
http://dx.doi.org/10.1155/2012/658745
_version_ 1782254721555234816
author Takemori, Nobuo
Kaneko, Hiroyuki
Nakamura, Masaya
Kojima, Masaru
author_facet Takemori, Nobuo
Kaneko, Hiroyuki
Nakamura, Masaya
Kojima, Masaru
author_sort Takemori, Nobuo
collection PubMed
description Patients with rheumatoid arthritis (RA) are known to develop lymphoproliferative disorders (LPDs) during the course of illness, particularly in cases treated with methotrexate (MTX) for long periods. We describe a case of MTX-related Epstein-Barr-virus-(EBV-) associated LPD resembling Hodgkin's lymphoma (HL), in which a dramatic complete remission was achieved after withdrawal of MTX coupled with clarithromycin (CAM) administration. Withdrawal of MTX coupled with CAM administration seemed to be effective for treating MTX-related EBV-associated LPDs. In particular, an immunomodulative effect of CAM might have been involved in achieving complete remission.
format Online
Article
Text
id pubmed-3535817
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-35358172013-01-11 Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin Administration Takemori, Nobuo Kaneko, Hiroyuki Nakamura, Masaya Kojima, Masaru Case Rep Hematol Case Report Patients with rheumatoid arthritis (RA) are known to develop lymphoproliferative disorders (LPDs) during the course of illness, particularly in cases treated with methotrexate (MTX) for long periods. We describe a case of MTX-related Epstein-Barr-virus-(EBV-) associated LPD resembling Hodgkin's lymphoma (HL), in which a dramatic complete remission was achieved after withdrawal of MTX coupled with clarithromycin (CAM) administration. Withdrawal of MTX coupled with CAM administration seemed to be effective for treating MTX-related EBV-associated LPDs. In particular, an immunomodulative effect of CAM might have been involved in achieving complete remission. Hindawi Publishing Corporation 2012 2012-12-19 /pmc/articles/PMC3535817/ /pubmed/23316401 http://dx.doi.org/10.1155/2012/658745 Text en Copyright © 2012 Nobuo Takemori et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Takemori, Nobuo
Kaneko, Hiroyuki
Nakamura, Masaya
Kojima, Masaru
Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin Administration
title Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin Administration
title_full Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin Administration
title_fullStr Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin Administration
title_full_unstemmed Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin Administration
title_short Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin Administration
title_sort complete remission of methotrexate-related epstein-barr-virus-associated hodgkin-like lymphoma following withdrawal of mtx coupled with clarithromycin administration
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535817/
https://www.ncbi.nlm.nih.gov/pubmed/23316401
http://dx.doi.org/10.1155/2012/658745
work_keys_str_mv AT takemorinobuo completeremissionofmethotrexaterelatedepsteinbarrvirusassociatedhodgkinlikelymphomafollowingwithdrawalofmtxcoupledwithclarithromycinadministration
AT kanekohiroyuki completeremissionofmethotrexaterelatedepsteinbarrvirusassociatedhodgkinlikelymphomafollowingwithdrawalofmtxcoupledwithclarithromycinadministration
AT nakamuramasaya completeremissionofmethotrexaterelatedepsteinbarrvirusassociatedhodgkinlikelymphomafollowingwithdrawalofmtxcoupledwithclarithromycinadministration
AT kojimamasaru completeremissionofmethotrexaterelatedepsteinbarrvirusassociatedhodgkinlikelymphomafollowingwithdrawalofmtxcoupledwithclarithromycinadministration

Ejemplares similares