Assessing the Effects of Estrogen on the Dynamics of Breast Cancer

Worldwide, breast cancer has become the second most common cancer in women. The disease has currently been named the most deadly cancer in women but little is known on what causes the disease. We present the effects of estrogen as a risk factor on the dynamics of breast cancer. We develop a determin...

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Detalles Bibliográficos
Autores principales: Mufudza, Chipo, Sorofa, Walter, Chiyaka, Edward T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536317/
https://www.ncbi.nlm.nih.gov/pubmed/23365616
http://dx.doi.org/10.1155/2012/473572
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author Mufudza, Chipo
Sorofa, Walter
Chiyaka, Edward T.
author_facet Mufudza, Chipo
Sorofa, Walter
Chiyaka, Edward T.
author_sort Mufudza, Chipo
collection PubMed
description Worldwide, breast cancer has become the second most common cancer in women. The disease has currently been named the most deadly cancer in women but little is known on what causes the disease. We present the effects of estrogen as a risk factor on the dynamics of breast cancer. We develop a deterministic mathematical model showing general dynamics of breast cancer with immune response. This is a four-population model that includes tumor cells, host cells, immune cells, and estrogen. The effects of estrogen are then incorporated in the model. The results show that the presence of extra estrogen increases the risk of developing breast cancer.
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spelling pubmed-35363172013-01-30 Assessing the Effects of Estrogen on the Dynamics of Breast Cancer Mufudza, Chipo Sorofa, Walter Chiyaka, Edward T. Comput Math Methods Med Research Article Worldwide, breast cancer has become the second most common cancer in women. The disease has currently been named the most deadly cancer in women but little is known on what causes the disease. We present the effects of estrogen as a risk factor on the dynamics of breast cancer. We develop a deterministic mathematical model showing general dynamics of breast cancer with immune response. This is a four-population model that includes tumor cells, host cells, immune cells, and estrogen. The effects of estrogen are then incorporated in the model. The results show that the presence of extra estrogen increases the risk of developing breast cancer. Hindawi Publishing Corporation 2012 2012-12-19 /pmc/articles/PMC3536317/ /pubmed/23365616 http://dx.doi.org/10.1155/2012/473572 Text en Copyright © 2012 Chipo Mufudza et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mufudza, Chipo
Sorofa, Walter
Chiyaka, Edward T.
Assessing the Effects of Estrogen on the Dynamics of Breast Cancer
title Assessing the Effects of Estrogen on the Dynamics of Breast Cancer
title_full Assessing the Effects of Estrogen on the Dynamics of Breast Cancer
title_fullStr Assessing the Effects of Estrogen on the Dynamics of Breast Cancer
title_full_unstemmed Assessing the Effects of Estrogen on the Dynamics of Breast Cancer
title_short Assessing the Effects of Estrogen on the Dynamics of Breast Cancer
title_sort assessing the effects of estrogen on the dynamics of breast cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536317/
https://www.ncbi.nlm.nih.gov/pubmed/23365616
http://dx.doi.org/10.1155/2012/473572
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