Effect of SMURF2 Targeting on Susceptibility to MEK Inhibitors in Melanoma

BACKGROUND: The mitogen-activated protein–kinase pathway consisting of the kinases RAF, MEK, and ERK is central to cell proliferation and survival and is deregulated in more than 90% of melanomas. MEK inhibitors are currently trialled in the clinic, but despite efficient target inhibition, cytostati...

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Detalles Bibliográficos
Autores principales: Smith, Michael P., Ferguson, Jennifer, Arozarena, Imanol, Hayward, Robert, Marais, Richard, Chapman, Anna, Hurlstone, Adam, Wellbrock, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536641/
https://www.ncbi.nlm.nih.gov/pubmed/23250956
http://dx.doi.org/10.1093/jnci/djs471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536641/
https://www.ncbi.nlm.nih.gov/pubmed/23250956
http://dx.doi.org/10.1093/jnci/djs471

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