Cargando…
Effect of SMURF2 Targeting on Susceptibility to MEK Inhibitors in Melanoma
BACKGROUND: The mitogen-activated protein–kinase pathway consisting of the kinases RAF, MEK, and ERK is central to cell proliferation and survival and is deregulated in more than 90% of melanomas. MEK inhibitors are currently trialled in the clinic, but despite efficient target inhibition, cytostati...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2013
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536641/ https://www.ncbi.nlm.nih.gov/pubmed/23250956 http://dx.doi.org/10.1093/jnci/djs471 |