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Genomic regions associated with bovine milk fatty acids in both summer and winter milk samples

BACKGROUND: In this study we perform a genome-wide association study (GWAS) for bovine milk fatty acids from summer milk samples. This study replicates a previous study where we performed a GWAS for bovine milk fatty acids based on winter milk samples from the same population. Fatty acids from summe...

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Autores principales: Bouwman, Aniek C, Visker, Marleen HPW, van Arendonk, Johan AM, Bovenhuis, Henk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536661/
https://www.ncbi.nlm.nih.gov/pubmed/23107417
http://dx.doi.org/10.1186/1471-2156-13-93
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author Bouwman, Aniek C
Visker, Marleen HPW
van Arendonk, Johan AM
Bovenhuis, Henk
author_facet Bouwman, Aniek C
Visker, Marleen HPW
van Arendonk, Johan AM
Bovenhuis, Henk
author_sort Bouwman, Aniek C
collection PubMed
description BACKGROUND: In this study we perform a genome-wide association study (GWAS) for bovine milk fatty acids from summer milk samples. This study replicates a previous study where we performed a GWAS for bovine milk fatty acids based on winter milk samples from the same population. Fatty acids from summer and winter milk are genetically similar traits and we therefore compare the regions detected in summer milk to the regions previously detected in winter milk GWAS to discover regions that explain genetic variation in both summer and winter milk. RESULTS: The GWAS of summer milk samples resulted in 51 regions associated with one or more milk fatty acids. Results are in agreement with most associations that were previously detected in a GWAS of fatty acids from winter milk samples, including eight ‘new’ regions that were not considered in the individual studies. The high correlation between the –log(10)(P-values) and effects of SNPs that were found significant in both GWAS imply that the effects of the SNPs were similar on winter and summer milk fatty acids. CONCLUSIONS: The GWAS of fatty acids based on summer milk samples was in agreement with most of the associations detected in the GWAS of fatty acids based on winter milk samples. Associations that were in agreement between both GWAS are more likely to be involved in fatty acid synthesis compared to regions detected in only one GWAS and are therefore worthwhile to pursue in fine-mapping studies.
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spelling pubmed-35366612013-01-08 Genomic regions associated with bovine milk fatty acids in both summer and winter milk samples Bouwman, Aniek C Visker, Marleen HPW van Arendonk, Johan AM Bovenhuis, Henk BMC Genet Research Article BACKGROUND: In this study we perform a genome-wide association study (GWAS) for bovine milk fatty acids from summer milk samples. This study replicates a previous study where we performed a GWAS for bovine milk fatty acids based on winter milk samples from the same population. Fatty acids from summer and winter milk are genetically similar traits and we therefore compare the regions detected in summer milk to the regions previously detected in winter milk GWAS to discover regions that explain genetic variation in both summer and winter milk. RESULTS: The GWAS of summer milk samples resulted in 51 regions associated with one or more milk fatty acids. Results are in agreement with most associations that were previously detected in a GWAS of fatty acids from winter milk samples, including eight ‘new’ regions that were not considered in the individual studies. The high correlation between the –log(10)(P-values) and effects of SNPs that were found significant in both GWAS imply that the effects of the SNPs were similar on winter and summer milk fatty acids. CONCLUSIONS: The GWAS of fatty acids based on summer milk samples was in agreement with most of the associations detected in the GWAS of fatty acids based on winter milk samples. Associations that were in agreement between both GWAS are more likely to be involved in fatty acid synthesis compared to regions detected in only one GWAS and are therefore worthwhile to pursue in fine-mapping studies. BioMed Central 2012-10-29 /pmc/articles/PMC3536661/ /pubmed/23107417 http://dx.doi.org/10.1186/1471-2156-13-93 Text en Copyright ©2012 Bouwman et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bouwman, Aniek C
Visker, Marleen HPW
van Arendonk, Johan AM
Bovenhuis, Henk
Genomic regions associated with bovine milk fatty acids in both summer and winter milk samples
title Genomic regions associated with bovine milk fatty acids in both summer and winter milk samples
title_full Genomic regions associated with bovine milk fatty acids in both summer and winter milk samples
title_fullStr Genomic regions associated with bovine milk fatty acids in both summer and winter milk samples
title_full_unstemmed Genomic regions associated with bovine milk fatty acids in both summer and winter milk samples
title_short Genomic regions associated with bovine milk fatty acids in both summer and winter milk samples
title_sort genomic regions associated with bovine milk fatty acids in both summer and winter milk samples
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536661/
https://www.ncbi.nlm.nih.gov/pubmed/23107417
http://dx.doi.org/10.1186/1471-2156-13-93
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