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Ranolazine inhibits shear sensitivity of endogenous Na(+) current and spontaneous action potentials in HL-1 cells

Na(V)1.5 is a mechanosensitive voltage-gated Na(+) channel encoded by the gene SCN5A, expressed in cardiac myocytes and required for phase 0 of the cardiac action potential (AP). In the cardiomyocyte, ranolazine inhibits depolarizing Na(+) current and delayed rectifier (I(Kr)) currents. Recently, ra...

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Detalles Bibliográficos
Autores principales:	Strege, Peter, Beyder, Arthur, Bernard, Cheryl, Crespo-Diaz, Ruben, Behfar, Atta, Terzic, Andre, Ackerman, Michael, Farrugia, Gianrico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2012
Materias:	Article Addendum
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536731/ https://www.ncbi.nlm.nih.gov/pubmed/23018927 http://dx.doi.org/10.4161/chan.22017

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