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State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1

We previously reported that TREK-1 gating by internal pH and pressure occurs close to or within the selectivity filter. These conclusions were based upon kinetic measurements of high-affinity block by quaternary ammonium (QA) ions that appeared to exhibit state-independent accessibility to their bin...

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Detalles Bibliográficos
Autores principales:	Rapedius, Markus, Schmidt, Matthias R., Sharma, Chetan, Stansfeld, Phillip J., Sansom, Mark S.P., Baukrowitz, Thomas, Tucker, Stephen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2012
Materias:	Article Addendum
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536734/ https://www.ncbi.nlm.nih.gov/pubmed/22991046 http://dx.doi.org/10.4161/chan.22153

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