Disruption of Smad7 Promotes ANG II-Mediated Renal Inflammation and Fibrosis via Sp1-TGF-β/Smad3-NF.κB-Dependent Mechanisms in Mice

Smad7 is an inhibitory Smad and plays a protective role in obstructive and diabetic kidney disease. However, the role and mechanisms of Smad7 in hypertensive nephropathy remains unexplored. Thus, the aim of this study was to investigate the role and regulatory mechanisms of Smad7 in ANG II-induced h...

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Detalles Bibliográficos
Autores principales: Liu, Guan-Xian, Li, You-Qi, Huang, Xiao R., Wei, Lihua, Chen, Hai-Yong, Shi, Yong-Jun, Heuchel, Rainer L., Lan, Hui Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536757/
https://www.ncbi.nlm.nih.gov/pubmed/23301086
http://dx.doi.org/10.1371/journal.pone.0053573

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