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Aminoimidazole Carboxamide Ribonucleotide (AICAR) Inhibits the Growth of Retinoblastoma In Vivo by Decreasing Angiogenesis and Inducing Apoptosis

5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR), an analog of AMP is widely used as an activator of AMP-kinase (AMPK), a protein that regulates the responses of the cell to energy change. Recently, we showed that AICAR-induced AMPK activation inhibits the growth of retinoblastoma cells i...

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Detalles Bibliográficos
Autores principales:	Theodoropoulou, Sofia, Brodowska, Katarzyna, Kayama, Maki, Morizane, Yuki, Miller, Joan W., Gragoudas, Evangelos S., Vavvas, Demetrios G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536763/ https://www.ncbi.nlm.nih.gov/pubmed/23300996 http://dx.doi.org/10.1371/journal.pone.0052852

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