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Reductive whole-cell biotransformation with Corynebacterium glutamicum: improvement of NADPH generation from glucose by a cyclized pentose phosphate pathway using pfkA and gapA deletion mutants

In this study, the potential of Corynebacterium glutamicum for reductive whole-cell biotransformation is shown. The NADPH-dependent reduction of the prochiral methyl acetoacetate (MAA) to the chiral (R)-methyl 3-hydroxybutyrate (MHB) by an alcohol dehydrogenase from Lactobacillus brevis (Lbadh) was...

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Detalles Bibliográficos
Autores principales:	Siedler, Solvej, Lindner, Steffen N., Bringer, Stephanie, Wendisch, Volker F., Bott, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2012
Materias:	Biotechnological Products and Process Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536970/ https://www.ncbi.nlm.nih.gov/pubmed/22851018 http://dx.doi.org/10.1007/s00253-012-4314-7

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