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New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters
Genome sequencing of Streptomyces, myxobacteria, and fungi showed that although each strain contains genes that encode the enzymes to synthesize a plethora of potential secondary metabolites, only a fraction are expressed during fermentation. Interest has therefore grown in the activation of these c...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer-Verlag
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536979/ https://www.ncbi.nlm.nih.gov/pubmed/23143535 http://dx.doi.org/10.1007/s00253-012-4551-9 |