Cargando…
Different Aspects of Kidney Function in Well-Controlled Congenital Hypothyroidism
Objective: Congenital hypothyroidism (CH) increases the prevalence of kidney and urogenital malformations. There are limited studies considering different aspects of kidney function in well-controlled CH patients. We evaluated some features of kidney function in euthyroid children with CH who have b...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537285/ https://www.ncbi.nlm.nih.gov/pubmed/23261862 http://dx.doi.org/10.4274/Jcrpe.811 |
_version_ | 1782254852571660288 |
---|---|
author | Gheissari, Alaleh Hashemipour, Mahin Khosravi, Pooya Adibi, Atoosa |
author_facet | Gheissari, Alaleh Hashemipour, Mahin Khosravi, Pooya Adibi, Atoosa |
author_sort | Gheissari, Alaleh |
collection | PubMed |
description | Objective: Congenital hypothyroidism (CH) increases the prevalence of kidney and urogenital malformations. There are limited studies considering different aspects of kidney function in well-controlled CH patients. We evaluated some features of kidney function in euthyroid children with CH who have been receiving thyroxine hormone since early life. Methods: This cross-sectional study was conducted in Isfahan, Iran, on 74 children aged 2-15 years old (36 CH patients and 38 healthy children). Inclusion criteria for CH patients were euthyroidism at the time of the survey and initiation of replacement therapy during the early neonatal period. Kidney ultrasound evaluation was performed in all participants. Serum biochemistry included urea, creatinine, sodium (Na), potassium (K), magnesium, calcium, and cystatin C levels. Urine electrolytes, fraction excretion (FE) of electrolytes and microalbumin, and glomerular filtration rate (GFR) were also determined. Results: The male/female ratio was 0.8/1 and 1.5/1 in the patient and control groups, respectively. Mean age and height did not differ significantly between the two groups. Ultrasound evaluation of the kidney revealed that the anteroposterior diameter of the right kidney was significantly higher in CH patients as compared to healthy subjects. No significant difference was observed between GFRs in patients with CH and healthy children. The mean values for FENa and FEK were significantly higher in the patient group. Conclusions: Increased FENa and FEK may be a manifestation of impaired tubular maturation in CH. More longitudinal studies are needed to evaluate kidney function in CH patients. Conflict of interest:None declared. |
format | Online Article Text |
id | pubmed-3537285 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-35372852013-01-04 Different Aspects of Kidney Function in Well-Controlled Congenital Hypothyroidism Gheissari, Alaleh Hashemipour, Mahin Khosravi, Pooya Adibi, Atoosa J Clin Res Pediatr Endocrinol Original Article Objective: Congenital hypothyroidism (CH) increases the prevalence of kidney and urogenital malformations. There are limited studies considering different aspects of kidney function in well-controlled CH patients. We evaluated some features of kidney function in euthyroid children with CH who have been receiving thyroxine hormone since early life. Methods: This cross-sectional study was conducted in Isfahan, Iran, on 74 children aged 2-15 years old (36 CH patients and 38 healthy children). Inclusion criteria for CH patients were euthyroidism at the time of the survey and initiation of replacement therapy during the early neonatal period. Kidney ultrasound evaluation was performed in all participants. Serum biochemistry included urea, creatinine, sodium (Na), potassium (K), magnesium, calcium, and cystatin C levels. Urine electrolytes, fraction excretion (FE) of electrolytes and microalbumin, and glomerular filtration rate (GFR) were also determined. Results: The male/female ratio was 0.8/1 and 1.5/1 in the patient and control groups, respectively. Mean age and height did not differ significantly between the two groups. Ultrasound evaluation of the kidney revealed that the anteroposterior diameter of the right kidney was significantly higher in CH patients as compared to healthy subjects. No significant difference was observed between GFRs in patients with CH and healthy children. The mean values for FENa and FEK were significantly higher in the patient group. Conclusions: Increased FENa and FEK may be a manifestation of impaired tubular maturation in CH. More longitudinal studies are needed to evaluate kidney function in CH patients. Conflict of interest:None declared. Galenos Publishing 2012-12 2012-12-19 /pmc/articles/PMC3537285/ /pubmed/23261862 http://dx.doi.org/10.4274/Jcrpe.811 Text en © Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Gheissari, Alaleh Hashemipour, Mahin Khosravi, Pooya Adibi, Atoosa Different Aspects of Kidney Function in Well-Controlled Congenital Hypothyroidism |
title | Different Aspects of Kidney Function in Well-Controlled Congenital Hypothyroidism |
title_full | Different Aspects of Kidney Function in Well-Controlled Congenital Hypothyroidism |
title_fullStr | Different Aspects of Kidney Function in Well-Controlled Congenital Hypothyroidism |
title_full_unstemmed | Different Aspects of Kidney Function in Well-Controlled Congenital Hypothyroidism |
title_short | Different Aspects of Kidney Function in Well-Controlled Congenital Hypothyroidism |
title_sort | different aspects of kidney function in well-controlled congenital hypothyroidism |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537285/ https://www.ncbi.nlm.nih.gov/pubmed/23261862 http://dx.doi.org/10.4274/Jcrpe.811 |
work_keys_str_mv | AT gheissarialaleh differentaspectsofkidneyfunctioninwellcontrolledcongenitalhypothyroidism AT hashemipourmahin differentaspectsofkidneyfunctioninwellcontrolledcongenitalhypothyroidism AT khosravipooya differentaspectsofkidneyfunctioninwellcontrolledcongenitalhypothyroidism AT adibiatoosa differentaspectsofkidneyfunctioninwellcontrolledcongenitalhypothyroidism |