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The pro-metastasis tyrosine phosphatase, PRL-3 (PTP4A3), is a novel mediator of oncogenic function of BCR-ABL in human chronic myeloid leukemia
BACKGROUND: Resistance to tyrosine kinase inhibitors (TKIs) remains a challenge in management of patients with chronic myeloid leukemia (CML). A better understanding of the BCR-ABL signalling network may lead to better therapy. FINDINGS: Here we report the discovery of a novel downstream target of B...
Autores principales: | Zhou, Jianbiao, Cheong, Lip-Lee, Liu, Shaw-Cheng, Chong, Phyllis SY, Mahara, Sylvia, Bi, Chonglei, Ong, Kelly OK, Zeng, Qi, Chng, Wee Joo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537646/ https://www.ncbi.nlm.nih.gov/pubmed/22995644 http://dx.doi.org/10.1186/1476-4598-11-72 |
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