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Structure-Function Relation of Phospholamban: Modulation of Channel Activity as a Potential Regulator of SERCA Activity

Phospholamban (PLN) is a small integral membrane protein, which binds and inhibits in a yet unknown fashion the Ca(2+)-ATPase (SERCA) in the sarcoplasmic reticulum. When reconstituted in planar lipid bilayers PLN exhibits ion channel activity with a low unitary conductance. From the effect of non-el...

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Detalles Bibliográficos
Autores principales:	Smeazzetto, Serena, Saponaro, Andrea, Young, Howard S., Moncelli, Maria Rosa, Thiel, Gerhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537670/ https://www.ncbi.nlm.nih.gov/pubmed/23308118 http://dx.doi.org/10.1371/journal.pone.0052744

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