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Highly efficient site-specific transgenesis in cancer cell lines
BACKGROUND: Transgenes introduced into cancer cell lines serve as powerful tools for identification of genes involved in cancer. However, the random nature of genomic integration site of a transgene highly influences the fidelity, reliability and level of its expression. In order to alleviate this b...
Autores principales: | Michael, Iacovos P, Monetti, Claudio, Chiu, Anthony C, Zhang, Puzheng, Baba, Takeshi, Nishino, Koichiro, Agha-Mohammadi, Siamak, Woltjen, Knut, Sung, Hoon-Ki, Nagy, Andras |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537676/ https://www.ncbi.nlm.nih.gov/pubmed/23231822 http://dx.doi.org/10.1186/1476-4598-11-89 |
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