Site–Specific Monoubiquitination Activates Ras by Impeding GTPase Activating Protein Function

Cell growth and differentiation are controlled by growth factor receptors coupled to the GTPase Ras. Oncogenic mutations disrupt GTPase activity leading to persistent Ras signaling and cancer progression. Recent evidence indicates that monoubiquitination of Ras leads to Ras activation. Mutation of t...

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Detalles Bibliográficos
Autores principales: Baker, Rachael, Lewis, Steven M., Sasaki, Atsuo T., Wilkerson, Emily M., Locasale, Jason W., Cantley, Lewis C., Kuhlman, Brian, Dohlman, Henrik G., Campbell, Sharon L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537887/
https://www.ncbi.nlm.nih.gov/pubmed/23178454
http://dx.doi.org/10.1038/nsmb.2430

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