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Short term serum pharmacokinetics of diammine silver fluoride after oral application
BACKGROUND: There is growing interest in the use of diammine silver fluoride (DSF) as a topical agent to treat dentin hypersensitivity and dental caries as gauged by increasing published research from many parts of the world. While DSF has been available in various formulations for many years, most...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538059/ https://www.ncbi.nlm.nih.gov/pubmed/23272643 http://dx.doi.org/10.1186/1472-6831-12-60 |
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author | Vasquez, Elsa Zegarra, Graciela Chirinos, Edgar Castillo, Jorge L Taves, Donald R Watson, Gene E Dills, Russell Mancl, Lloyd L Milgrom, Peter |
author_facet | Vasquez, Elsa Zegarra, Graciela Chirinos, Edgar Castillo, Jorge L Taves, Donald R Watson, Gene E Dills, Russell Mancl, Lloyd L Milgrom, Peter |
author_sort | Vasquez, Elsa |
collection | PubMed |
description | BACKGROUND: There is growing interest in the use of diammine silver fluoride (DSF) as a topical agent to treat dentin hypersensitivity and dental caries as gauged by increasing published research from many parts of the world. While DSF has been available in various formulations for many years, most of its pharmacokinetic aspects within the therapeutic concentration range have never been fully characterized. METHODS: This preliminary study determined the applied doses (3 teeth treated), maximum serum concentrations, and time to maximum serum concentration for fluoride and silver in 6 adults over 4 h. Fluoride was determined using the indirect diffusion method with a fluoride selective electrode, and silver was determined using inductively coupled plasma-mass spectrometry. The mean amount of DSF solution applied to the 3 teeth was 7.57 mg (6.04 μL). RESULTS: Over the 4 hour observation period, the mean maximum serum concentrations were 1.86 μmol/L for fluoride and 206 nmol/L for silver. These maximums were reached 3.0 h and 2.5 h for fluoride and silver, respectively. CONCLUSIONS: Fluoride exposure was below the U.S. Environmental Protection Agency (EPA) oral reference dose. Silver exposure exceeded the EPA oral reference dose for cumulative daily exposure over a lifetime, but for occasional use was well below concentrations associated with toxicity. This preliminary study suggests that serum concentrations of fluoride and silver after topical application of DSF should pose little toxicity risk when used in adults. CLINICAL TRIALS REGISTRATION: NCT01664871. |
format | Online Article Text |
id | pubmed-3538059 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35380592013-01-10 Short term serum pharmacokinetics of diammine silver fluoride after oral application Vasquez, Elsa Zegarra, Graciela Chirinos, Edgar Castillo, Jorge L Taves, Donald R Watson, Gene E Dills, Russell Mancl, Lloyd L Milgrom, Peter BMC Oral Health Research Article BACKGROUND: There is growing interest in the use of diammine silver fluoride (DSF) as a topical agent to treat dentin hypersensitivity and dental caries as gauged by increasing published research from many parts of the world. While DSF has been available in various formulations for many years, most of its pharmacokinetic aspects within the therapeutic concentration range have never been fully characterized. METHODS: This preliminary study determined the applied doses (3 teeth treated), maximum serum concentrations, and time to maximum serum concentration for fluoride and silver in 6 adults over 4 h. Fluoride was determined using the indirect diffusion method with a fluoride selective electrode, and silver was determined using inductively coupled plasma-mass spectrometry. The mean amount of DSF solution applied to the 3 teeth was 7.57 mg (6.04 μL). RESULTS: Over the 4 hour observation period, the mean maximum serum concentrations were 1.86 μmol/L for fluoride and 206 nmol/L for silver. These maximums were reached 3.0 h and 2.5 h for fluoride and silver, respectively. CONCLUSIONS: Fluoride exposure was below the U.S. Environmental Protection Agency (EPA) oral reference dose. Silver exposure exceeded the EPA oral reference dose for cumulative daily exposure over a lifetime, but for occasional use was well below concentrations associated with toxicity. This preliminary study suggests that serum concentrations of fluoride and silver after topical application of DSF should pose little toxicity risk when used in adults. CLINICAL TRIALS REGISTRATION: NCT01664871. BioMed Central 2012-12-31 /pmc/articles/PMC3538059/ /pubmed/23272643 http://dx.doi.org/10.1186/1472-6831-12-60 Text en Copyright ©2012 Vasquez et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Vasquez, Elsa Zegarra, Graciela Chirinos, Edgar Castillo, Jorge L Taves, Donald R Watson, Gene E Dills, Russell Mancl, Lloyd L Milgrom, Peter Short term serum pharmacokinetics of diammine silver fluoride after oral application |
title | Short term serum pharmacokinetics of diammine silver fluoride after oral application |
title_full | Short term serum pharmacokinetics of diammine silver fluoride after oral application |
title_fullStr | Short term serum pharmacokinetics of diammine silver fluoride after oral application |
title_full_unstemmed | Short term serum pharmacokinetics of diammine silver fluoride after oral application |
title_short | Short term serum pharmacokinetics of diammine silver fluoride after oral application |
title_sort | short term serum pharmacokinetics of diammine silver fluoride after oral application |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538059/ https://www.ncbi.nlm.nih.gov/pubmed/23272643 http://dx.doi.org/10.1186/1472-6831-12-60 |
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