In Vitro and In Vivo Studies of IgG-derived Treg Epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity

Tregitopes are regulatory T cell epitopes derived from immunoglobulin G (IgG) that stimulate CD25(+) FoxP3(+) T cells to expand. In conjunction with these Tregs, Tregitopes can prevent, treat, and even cure autoimmune disease in mouse models, suppress allo-specific responses in murine transplant mod...

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Detalles Bibliográficos
Autores principales: Cousens, Leslie P., Najafian, Nader, Mingozzi, Federico, Elyaman, Wassim, Mazer, Bruce, Moise, Leonard, Messitt, Timothy J., Su, Yan, Sayegh, Mohamed, High, Katherine, Khoury, Samia J., Scott, David W., De Groot, Anne S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538121/
https://www.ncbi.nlm.nih.gov/pubmed/22941509
http://dx.doi.org/10.1007/s10875-012-9762-4

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