Brain Ischemia Activates β- and γ-Secretase Cleavage of Amyloid Precursor Protein: Significance in Sporadic Alzheimer’s Disease

Amyloid precursor protein cleavage through β- and γ-secretases produces β-amyloid peptide, which is believed to be responsible for death of neurons and dementia in Alzheimer’s disease. Levels of β- and γ-secretase are increased in sensitive areas of the Alzheimer’s disease brain, but the mechanism o...

Descripción completa

Detalles Bibliográficos
Autores principales: Pluta, Ryszard, Furmaga-Jabłońska, Wanda, Maciejewski, Ryszard, Ułamek-Kozioł, Marzena, Jabłoński, Mirosław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Humana Press Inc 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538125/
https://www.ncbi.nlm.nih.gov/pubmed/23080191
http://dx.doi.org/10.1007/s12035-012-8360-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538125/
https://www.ncbi.nlm.nih.gov/pubmed/23080191
http://dx.doi.org/10.1007/s12035-012-8360-z

Ejemplares similares