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Somatization Severity Associated with Postero-Medial Complex Structures

Somatisation is a frequent problem in various psychiatric disorders, yet the cerebral mechanisms of somatisation remain unexamined. To test if somatisation is susceptible to emotional states, we investigated relationships between somatisation severity, neural effective connectivity, and autonomic re...

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Autores principales: Lemche, Erwin, Giampietro, Vincent P., Brammer, Michael J., Surguladze, Simon A., Williams, Steven C. R., Phillips, Mary L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538283/
https://www.ncbi.nlm.nih.gov/pubmed/23301153
http://dx.doi.org/10.1038/srep01032
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author Lemche, Erwin
Giampietro, Vincent P.
Brammer, Michael J.
Surguladze, Simon A.
Williams, Steven C. R.
Phillips, Mary L.
author_facet Lemche, Erwin
Giampietro, Vincent P.
Brammer, Michael J.
Surguladze, Simon A.
Williams, Steven C. R.
Phillips, Mary L.
author_sort Lemche, Erwin
collection PubMed
description Somatisation is a frequent problem in various psychiatric disorders, yet the cerebral mechanisms of somatisation remain unexamined. To test if somatisation is susceptible to emotional states, we investigated relationships between somatisation severity, neural effective connectivity, and autonomic responses to emotional facial expressions. Volunteering participants (N = 20) were presented with facial expressions of happy and sad emotion at three intensity levels (0%–50%–100%) in a fast implicit ER-fMRI design with concurrent derivation of skin conductance levels (SCL). Self-reported somatisation severity as assessed with Rief's SOMS-2 index was correlated with neural response controlling for other clinical traits to ascertain brain bases of somatisation. Regression analyses estimated effective connectivity of main clusters so determined with peripheral autonomic responses. Regions in which magnitude of activity correlated with somatisation severity consisted in both happy and sad conditions of the anterior ventral precuneus (BA7), along with posterior cingulate gyrus (PCC, BA23, sad condition) and anteromedial thalamus (happy condition).
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spelling pubmed-35382832013-01-08 Somatization Severity Associated with Postero-Medial Complex Structures Lemche, Erwin Giampietro, Vincent P. Brammer, Michael J. Surguladze, Simon A. Williams, Steven C. R. Phillips, Mary L. Sci Rep Article Somatisation is a frequent problem in various psychiatric disorders, yet the cerebral mechanisms of somatisation remain unexamined. To test if somatisation is susceptible to emotional states, we investigated relationships between somatisation severity, neural effective connectivity, and autonomic responses to emotional facial expressions. Volunteering participants (N = 20) were presented with facial expressions of happy and sad emotion at three intensity levels (0%–50%–100%) in a fast implicit ER-fMRI design with concurrent derivation of skin conductance levels (SCL). Self-reported somatisation severity as assessed with Rief's SOMS-2 index was correlated with neural response controlling for other clinical traits to ascertain brain bases of somatisation. Regression analyses estimated effective connectivity of main clusters so determined with peripheral autonomic responses. Regions in which magnitude of activity correlated with somatisation severity consisted in both happy and sad conditions of the anterior ventral precuneus (BA7), along with posterior cingulate gyrus (PCC, BA23, sad condition) and anteromedial thalamus (happy condition). Nature Publishing Group 2013-01-07 /pmc/articles/PMC3538283/ /pubmed/23301153 http://dx.doi.org/10.1038/srep01032 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Lemche, Erwin
Giampietro, Vincent P.
Brammer, Michael J.
Surguladze, Simon A.
Williams, Steven C. R.
Phillips, Mary L.
Somatization Severity Associated with Postero-Medial Complex Structures
title Somatization Severity Associated with Postero-Medial Complex Structures
title_full Somatization Severity Associated with Postero-Medial Complex Structures
title_fullStr Somatization Severity Associated with Postero-Medial Complex Structures
title_full_unstemmed Somatization Severity Associated with Postero-Medial Complex Structures
title_short Somatization Severity Associated with Postero-Medial Complex Structures
title_sort somatization severity associated with postero-medial complex structures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538283/
https://www.ncbi.nlm.nih.gov/pubmed/23301153
http://dx.doi.org/10.1038/srep01032
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