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Luminal B tumors are the most frequent molecular subtype in breast cancer of North African women: an immunohistochemical profile study from Morocco
BACKGROUND: Breast cancer may be classified into luminal A, luminal B, HER2+/ER-, basal-like and normal-like subtypes based on gene expression profiling or immunohistochemical (IHC) characteristics. The aim of our study is to show the molecular profile characteristic of breast cancer in the North Af...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538531/ https://www.ncbi.nlm.nih.gov/pubmed/23216981 http://dx.doi.org/10.1186/1746-1596-7-170 |
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author | El Fatemi, Hinde Chahbouni, Sanae Jayi, Sofia Moumna, Kaoutar Melhouf, My Abdelilah Bannani, Abdelaziz Mesbahi, Omar Amarti, Afaf |
author_facet | El Fatemi, Hinde Chahbouni, Sanae Jayi, Sofia Moumna, Kaoutar Melhouf, My Abdelilah Bannani, Abdelaziz Mesbahi, Omar Amarti, Afaf |
author_sort | El Fatemi, Hinde |
collection | PubMed |
description | BACKGROUND: Breast cancer may be classified into luminal A, luminal B, HER2+/ER-, basal-like and normal-like subtypes based on gene expression profiling or immunohistochemical (IHC) characteristics. The aim of our study is to show the molecular profile characteristic of breast cancer in the North African population of Morocco. This work showed preliminary results and correlations with clinicopathological and histological parameters. Three hundred and ninety primary breast carcinomas tumor tissues were immunostained for ER, PR, HER2, CK5/6, CK8/18 and Ki67 using paraffin tissue. METHODS: We reviewed 390 cases of breast cancer diagnosed on January 2008 to December 2011 at the Department of pathology, Hassan II teaching hospital, Fez, Morocco. Age, size tumor, metastatic profile, node involvement profile, histological type and immunohistochemical profile were studied. RESULTS: The average age was 46 years; our patients were diagnosed late with a high average tumor size. Luminal B subtype was more prevalent (41.8%), followed by luminal A (30.5%), basal-like (13, 6%), Her2-overexpressing (9, 2%), and unclassified subtype (4.9%). CONCLUSION: This study showed that molecular classification and biological profile may be different according to geographical distribution, to encourage further studies to know the genomic profile of tumors and the environment. VIRTUAL SLIDE: http://www.diagnosticpathology.diagnomx.eu/vs/1675272504826544 |
format | Online Article Text |
id | pubmed-3538531 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35385312013-01-10 Luminal B tumors are the most frequent molecular subtype in breast cancer of North African women: an immunohistochemical profile study from Morocco El Fatemi, Hinde Chahbouni, Sanae Jayi, Sofia Moumna, Kaoutar Melhouf, My Abdelilah Bannani, Abdelaziz Mesbahi, Omar Amarti, Afaf Diagn Pathol Short Report BACKGROUND: Breast cancer may be classified into luminal A, luminal B, HER2+/ER-, basal-like and normal-like subtypes based on gene expression profiling or immunohistochemical (IHC) characteristics. The aim of our study is to show the molecular profile characteristic of breast cancer in the North African population of Morocco. This work showed preliminary results and correlations with clinicopathological and histological parameters. Three hundred and ninety primary breast carcinomas tumor tissues were immunostained for ER, PR, HER2, CK5/6, CK8/18 and Ki67 using paraffin tissue. METHODS: We reviewed 390 cases of breast cancer diagnosed on January 2008 to December 2011 at the Department of pathology, Hassan II teaching hospital, Fez, Morocco. Age, size tumor, metastatic profile, node involvement profile, histological type and immunohistochemical profile were studied. RESULTS: The average age was 46 years; our patients were diagnosed late with a high average tumor size. Luminal B subtype was more prevalent (41.8%), followed by luminal A (30.5%), basal-like (13, 6%), Her2-overexpressing (9, 2%), and unclassified subtype (4.9%). CONCLUSION: This study showed that molecular classification and biological profile may be different according to geographical distribution, to encourage further studies to know the genomic profile of tumors and the environment. VIRTUAL SLIDE: http://www.diagnosticpathology.diagnomx.eu/vs/1675272504826544 BioMed Central 2012-12-07 /pmc/articles/PMC3538531/ /pubmed/23216981 http://dx.doi.org/10.1186/1746-1596-7-170 Text en Copyright ©2012 EL FATEMI; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report El Fatemi, Hinde Chahbouni, Sanae Jayi, Sofia Moumna, Kaoutar Melhouf, My Abdelilah Bannani, Abdelaziz Mesbahi, Omar Amarti, Afaf Luminal B tumors are the most frequent molecular subtype in breast cancer of North African women: an immunohistochemical profile study from Morocco |
title | Luminal B tumors are the most frequent molecular subtype in breast cancer of North African women: an immunohistochemical profile study from Morocco |
title_full | Luminal B tumors are the most frequent molecular subtype in breast cancer of North African women: an immunohistochemical profile study from Morocco |
title_fullStr | Luminal B tumors are the most frequent molecular subtype in breast cancer of North African women: an immunohistochemical profile study from Morocco |
title_full_unstemmed | Luminal B tumors are the most frequent molecular subtype in breast cancer of North African women: an immunohistochemical profile study from Morocco |
title_short | Luminal B tumors are the most frequent molecular subtype in breast cancer of North African women: an immunohistochemical profile study from Morocco |
title_sort | luminal b tumors are the most frequent molecular subtype in breast cancer of north african women: an immunohistochemical profile study from morocco |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538531/ https://www.ncbi.nlm.nih.gov/pubmed/23216981 http://dx.doi.org/10.1186/1746-1596-7-170 |
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