Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice

BACKGROUND: A proline-to-serine substitution at position-56 (P56S) of vesicle-associated membrane protein-associated protein B (VAPB) causes a form of dominantly inherited motor neuron disease (MND), including typical and atypical amyotrophic lateral sclerosis (ALS) and a mild late-onset spinal musc...

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Detalles Bibliográficos
Autores principales: Qiu, Linghua, Qiao, Tao, Beers, Melissa, Tan, Weijia, Wang, Hongyan, Yang, Bin, Xu, Zuoshang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538568/
https://www.ncbi.nlm.nih.gov/pubmed/23281774
http://dx.doi.org/10.1186/1750-1326-8-1

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