Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine

BACKGROUND: Purine nucleotides exhibit various functions in cellular metabolism. Besides serving as building blocks for nucleic acid synthesis, they participate in signaling pathways and energy metabolism. Further, IMP and GMP represent industrially relevant biotechnological products used as flavor...

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Detalles Bibliográficos
Autores principales: Peifer, Susanne, Barduhn, Tobias, Zimmet, Sarah, Volmer, Dietrich A, Heinzle, Elmar, Schneider, Konstantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538647/
https://www.ncbi.nlm.nih.gov/pubmed/23092390
http://dx.doi.org/10.1186/1475-2859-11-138

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