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Design, Synthesis and Biological Evaluation of Novel Piperazine Derivatives as CCR5 Antagonists

By using a fragment-assembly strategy and bioisosteric-replacement principle, a series of novel piperazine derivatives were designed, synthesized, and evaluated for their cellular target-effector fusion activities and in vitro antiviral activities against HIV-1. Preliminary structure-activity relati...

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Detalles Bibliográficos
Autores principales:	Liu, Tao, Weng, Zhiyong, Dong, Xiaowu, Chen, Linjie, Ma, Ling, Cen, Shan, Zhou, Naiming, Hu, Yongzhou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538727/ https://www.ncbi.nlm.nih.gov/pubmed/23308267 http://dx.doi.org/10.1371/journal.pone.0053636

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