Cargando…
Association between Selected Oral Pathogens and Gastric Precancerous Lesions
We examined whether colonization of selected oral pathogens is associated with gastric precancerous lesions in a cross-sectional study. A total of 119 participants were included, of which 37 were cases of chronic atrophic gastritis, intestinal metaplasia, or dysplasia. An oral examination was perfor...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538744/ https://www.ncbi.nlm.nih.gov/pubmed/23308100 http://dx.doi.org/10.1371/journal.pone.0051604 |
_version_ | 1782255007225085952 |
---|---|
author | Salazar, Christian R. Sun, Jinghua Li, Yihong Francois, Fritz Corby, Patricia Perez-Perez, Guillermo Dasanayake, Ananda Pei, Zhiheng Chen, Yu |
author_facet | Salazar, Christian R. Sun, Jinghua Li, Yihong Francois, Fritz Corby, Patricia Perez-Perez, Guillermo Dasanayake, Ananda Pei, Zhiheng Chen, Yu |
author_sort | Salazar, Christian R. |
collection | PubMed |
description | We examined whether colonization of selected oral pathogens is associated with gastric precancerous lesions in a cross-sectional study. A total of 119 participants were included, of which 37 were cases of chronic atrophic gastritis, intestinal metaplasia, or dysplasia. An oral examination was performed to measure periodontal indices. Plaque and saliva samples were tested with real-time quantitative PCR for DNA levels of pathogens related to periodontal disease (Porphyromonas gingivalis, Tannerella forsythensis, Treponema denticola, Actinobacillus actinomycetemcomitans) and dental caries (Streptococcus mutans and S. sobrinus). There were no consistent associations between DNA levels of selected bacterial species and gastric precancerous lesions, although an elevated but non-significant odds ratio (OR) for gastric precancerous lesions was observed in relation to increasing colonization of A. actinomycetemcomitans (OR = 1.36 for one standard deviation increase, 95% Confidence Interval = 0.87–2.12), P. gingivalis (OR = 1.12, 0.67–1.88) and T. denticola (OR = 1.34, 0.83–2.12) measured in plaque. To assess the influence of specific long-term infection, stratified analyses by levels of periodontal indices were conducted. A. actinomycetemcomitans was significantly associated with gastric precancerous lesions (OR = 2.51, 1.13–5.56) among those with ≥ median of percent tooth sites with PD≥3 mm, compared with no association among those below the median (OR = 0.86, 0.43–1.72). A significantly stronger relationship was observed between the cumulative bacterial burden score of periodontal disease-related pathogens and gastric precancerous lesions among those with higher versus lower levels of periodontal disease indices (p-values for interactions: 0.03–0.06). Among individuals with periodontal disease, high levels of colonization of periodontal pathogens are associated with an increased risk of gastric precancerous lesions. |
format | Online Article Text |
id | pubmed-3538744 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35387442013-01-10 Association between Selected Oral Pathogens and Gastric Precancerous Lesions Salazar, Christian R. Sun, Jinghua Li, Yihong Francois, Fritz Corby, Patricia Perez-Perez, Guillermo Dasanayake, Ananda Pei, Zhiheng Chen, Yu PLoS One Research Article We examined whether colonization of selected oral pathogens is associated with gastric precancerous lesions in a cross-sectional study. A total of 119 participants were included, of which 37 were cases of chronic atrophic gastritis, intestinal metaplasia, or dysplasia. An oral examination was performed to measure periodontal indices. Plaque and saliva samples were tested with real-time quantitative PCR for DNA levels of pathogens related to periodontal disease (Porphyromonas gingivalis, Tannerella forsythensis, Treponema denticola, Actinobacillus actinomycetemcomitans) and dental caries (Streptococcus mutans and S. sobrinus). There were no consistent associations between DNA levels of selected bacterial species and gastric precancerous lesions, although an elevated but non-significant odds ratio (OR) for gastric precancerous lesions was observed in relation to increasing colonization of A. actinomycetemcomitans (OR = 1.36 for one standard deviation increase, 95% Confidence Interval = 0.87–2.12), P. gingivalis (OR = 1.12, 0.67–1.88) and T. denticola (OR = 1.34, 0.83–2.12) measured in plaque. To assess the influence of specific long-term infection, stratified analyses by levels of periodontal indices were conducted. A. actinomycetemcomitans was significantly associated with gastric precancerous lesions (OR = 2.51, 1.13–5.56) among those with ≥ median of percent tooth sites with PD≥3 mm, compared with no association among those below the median (OR = 0.86, 0.43–1.72). A significantly stronger relationship was observed between the cumulative bacterial burden score of periodontal disease-related pathogens and gastric precancerous lesions among those with higher versus lower levels of periodontal disease indices (p-values for interactions: 0.03–0.06). Among individuals with periodontal disease, high levels of colonization of periodontal pathogens are associated with an increased risk of gastric precancerous lesions. Public Library of Science 2013-01-07 /pmc/articles/PMC3538744/ /pubmed/23308100 http://dx.doi.org/10.1371/journal.pone.0051604 Text en © 2013 Salazar et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Salazar, Christian R. Sun, Jinghua Li, Yihong Francois, Fritz Corby, Patricia Perez-Perez, Guillermo Dasanayake, Ananda Pei, Zhiheng Chen, Yu Association between Selected Oral Pathogens and Gastric Precancerous Lesions |
title | Association between Selected Oral Pathogens and Gastric Precancerous Lesions |
title_full | Association between Selected Oral Pathogens and Gastric Precancerous Lesions |
title_fullStr | Association between Selected Oral Pathogens and Gastric Precancerous Lesions |
title_full_unstemmed | Association between Selected Oral Pathogens and Gastric Precancerous Lesions |
title_short | Association between Selected Oral Pathogens and Gastric Precancerous Lesions |
title_sort | association between selected oral pathogens and gastric precancerous lesions |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538744/ https://www.ncbi.nlm.nih.gov/pubmed/23308100 http://dx.doi.org/10.1371/journal.pone.0051604 |
work_keys_str_mv | AT salazarchristianr associationbetweenselectedoralpathogensandgastricprecancerouslesions AT sunjinghua associationbetweenselectedoralpathogensandgastricprecancerouslesions AT liyihong associationbetweenselectedoralpathogensandgastricprecancerouslesions AT francoisfritz associationbetweenselectedoralpathogensandgastricprecancerouslesions AT corbypatricia associationbetweenselectedoralpathogensandgastricprecancerouslesions AT perezperezguillermo associationbetweenselectedoralpathogensandgastricprecancerouslesions AT dasanayakeananda associationbetweenselectedoralpathogensandgastricprecancerouslesions AT peizhiheng associationbetweenselectedoralpathogensandgastricprecancerouslesions AT chenyu associationbetweenselectedoralpathogensandgastricprecancerouslesions |