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A Unified Model of the GABA(A) Receptor Comprising Agonist and Benzodiazepine Binding Sites

We present a full-length α(1)β(2)γ(2) GABA receptor model optimized for agonists and benzodiazepine (BZD) allosteric modulators. We propose binding hypotheses for the agonists GABA, muscimol and THIP and for the allosteric modulator diazepam (DZP). The receptor model is primarily based on the glutam...

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Detalles Bibliográficos
Autores principales:	Bergmann, Rikke, Kongsbak, Kristine, Sørensen, Pernille Louise, Sander, Tommy, Balle, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538749/ https://www.ncbi.nlm.nih.gov/pubmed/23308109 http://dx.doi.org/10.1371/journal.pone.0052323

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