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Magnetoencephalography Interictal Spike Clustering in Relation with Surgical Outcome of Cortical Dysplasia

OBJECTIVE: The aim of this study was to devise an objective clustering method for magnetoencephalography (MEG) interictal spike sources, and to identify the prognostic value of the new clustering method in adult epilepsy patients with cortical dysplasia (CD). METHODS: We retrospectively analyzed 25...

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Autores principales: Jeong, Woorim, Chung, Chun Kee, Kim, June Sic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Neurosurgical Society 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539081/
https://www.ncbi.nlm.nih.gov/pubmed/23323167
http://dx.doi.org/10.3340/jkns.2012.52.5.466
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author Jeong, Woorim
Chung, Chun Kee
Kim, June Sic
author_facet Jeong, Woorim
Chung, Chun Kee
Kim, June Sic
author_sort Jeong, Woorim
collection PubMed
description OBJECTIVE: The aim of this study was to devise an objective clustering method for magnetoencephalography (MEG) interictal spike sources, and to identify the prognostic value of the new clustering method in adult epilepsy patients with cortical dysplasia (CD). METHODS: We retrospectively analyzed 25 adult patients with histologically proven CD, who underwent MEG examination and surgical resection for intractable epilepsy. The mean postoperative follow-up period was 3.1 years. A hierarchical clustering method was adopted for MEG interictal spike source clustering. Clustered sources were then tested for their prognostic value toward surgical outcome. RESULTS: Postoperative seizure outcome was Engel class I in 6 (24%), class II in 3 (12%), class III in 12 (48%), and class IV in 4 (16%) patients. With respect to MEG spike clustering, 12 of 25 (48%) patients showed 1 cluster, 2 (8%) showed 2 or more clusters within the same lobe, 10 (40%) showed 2 or more clusters in a different lobe, and 1 (4%) patient had only scattered spikes with no clustering. Patients who showed focal clustering achieved better surgical outcome than distributed cases (p=0.017). CONCLUSION: This is the first study that introduces an objective method to classify the distribution of MEG interictal spike sources. By using a hierarchical clustering method, we found that the presence of focal clustered spikes predicts a better postoperative outcome in epilepsy patients with CD.
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spelling pubmed-35390812013-01-15 Magnetoencephalography Interictal Spike Clustering in Relation with Surgical Outcome of Cortical Dysplasia Jeong, Woorim Chung, Chun Kee Kim, June Sic J Korean Neurosurg Soc Clinical Article OBJECTIVE: The aim of this study was to devise an objective clustering method for magnetoencephalography (MEG) interictal spike sources, and to identify the prognostic value of the new clustering method in adult epilepsy patients with cortical dysplasia (CD). METHODS: We retrospectively analyzed 25 adult patients with histologically proven CD, who underwent MEG examination and surgical resection for intractable epilepsy. The mean postoperative follow-up period was 3.1 years. A hierarchical clustering method was adopted for MEG interictal spike source clustering. Clustered sources were then tested for their prognostic value toward surgical outcome. RESULTS: Postoperative seizure outcome was Engel class I in 6 (24%), class II in 3 (12%), class III in 12 (48%), and class IV in 4 (16%) patients. With respect to MEG spike clustering, 12 of 25 (48%) patients showed 1 cluster, 2 (8%) showed 2 or more clusters within the same lobe, 10 (40%) showed 2 or more clusters in a different lobe, and 1 (4%) patient had only scattered spikes with no clustering. Patients who showed focal clustering achieved better surgical outcome than distributed cases (p=0.017). CONCLUSION: This is the first study that introduces an objective method to classify the distribution of MEG interictal spike sources. By using a hierarchical clustering method, we found that the presence of focal clustered spikes predicts a better postoperative outcome in epilepsy patients with CD. The Korean Neurosurgical Society 2012-11 2012-11-30 /pmc/articles/PMC3539081/ /pubmed/23323167 http://dx.doi.org/10.3340/jkns.2012.52.5.466 Text en Copyright © 2012 The Korean Neurosurgical Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Article
Jeong, Woorim
Chung, Chun Kee
Kim, June Sic
Magnetoencephalography Interictal Spike Clustering in Relation with Surgical Outcome of Cortical Dysplasia
title Magnetoencephalography Interictal Spike Clustering in Relation with Surgical Outcome of Cortical Dysplasia
title_full Magnetoencephalography Interictal Spike Clustering in Relation with Surgical Outcome of Cortical Dysplasia
title_fullStr Magnetoencephalography Interictal Spike Clustering in Relation with Surgical Outcome of Cortical Dysplasia
title_full_unstemmed Magnetoencephalography Interictal Spike Clustering in Relation with Surgical Outcome of Cortical Dysplasia
title_short Magnetoencephalography Interictal Spike Clustering in Relation with Surgical Outcome of Cortical Dysplasia
title_sort magnetoencephalography interictal spike clustering in relation with surgical outcome of cortical dysplasia
topic Clinical Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539081/
https://www.ncbi.nlm.nih.gov/pubmed/23323167
http://dx.doi.org/10.3340/jkns.2012.52.5.466
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