Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity

The expression of acid ceramidase (AC) – a cysteine amidase that hydrolyses the proapoptotic lipid ceramide – is abnormally high in several human tumors, which is suggestive of a role in chemoresistance. Available AC inhibitors lack, however, the potency and drug-likeness necessary to test this idea...

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Detalles Bibliográficos
Autores principales: Realini, Natalia, Solorzano, Carlos, Pagliuca, Chiara, Pizzirani, Daniela, Armirotti, Andrea, Luciani, Rosaria, Costi, Maria Paola, Bandiera, Tiziano, Piomelli, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539145/
https://www.ncbi.nlm.nih.gov/pubmed/23301156
http://dx.doi.org/10.1038/srep01035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539145/
https://www.ncbi.nlm.nih.gov/pubmed/23301156
http://dx.doi.org/10.1038/srep01035

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