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The structural basis of direct glucocorticoid-mediated transrepression

A newly discovered negative glucocorticoid response element (nGRE) mediates DNA-dependent transrepression by the glucocorticoid receptor (GR) across the genome and plays a major role in immunosuppressive therapy. The nGRE differs dramatically from activating response elements and the mechanism drivi...

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Detalles Bibliográficos
Autores principales:	Hudson, William H., Youn, Christine, Ortlund, Eric A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539207/ https://www.ncbi.nlm.nih.gov/pubmed/23222642 http://dx.doi.org/10.1038/nsmb.2456

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