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Switching and Escalating Therapy in Long-Lasting Multiple Sclerosis: Not Always Necessary

Although therapy switch is common among patients with multiple sclerosis (MS), sometimes the initial prescribed treatment is maintained for a long period with clinical stability, low disability, and nonsignificant side effects. We aim to describe demographic and clinical characteristics of patients...

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Detalles Bibliográficos
Autores principales: Carvalho, Ana Teresa, Sá, Maria José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539327/
https://www.ncbi.nlm.nih.gov/pubmed/23316389
http://dx.doi.org/10.5402/2012/451457
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author Carvalho, Ana Teresa
Sá, Maria José
author_facet Carvalho, Ana Teresa
Sá, Maria José
author_sort Carvalho, Ana Teresa
collection PubMed
description Although therapy switch is common among patients with multiple sclerosis (MS), sometimes the initial prescribed treatment is maintained for a long period with clinical stability, low disability, and nonsignificant side effects. We aim to describe demographic and clinical characteristics of patients treated in our MS clinic with the same disease-modifying drug (DMD) lasting for >12 years. From the cohort of 51 patients followed in our MS clinic with relapse-remitting MS who started an DMD between 1996 and 1999, we found a high percentage (51%) of patients who were efficiently treated with the first DMD. These patients were mainly females, with low annualized relapse rate and Multiple Sclerosis Severity Score (MSSS). Our results may be related to the open and multidisciplinary model of our MS clinic organization. Identifying characteristics associated with therapy persistence may be useful in developing strategies to improve therapy effectiveness.
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spelling pubmed-35393272013-01-11 Switching and Escalating Therapy in Long-Lasting Multiple Sclerosis: Not Always Necessary Carvalho, Ana Teresa Sá, Maria José ISRN Neurol Clinical Study Although therapy switch is common among patients with multiple sclerosis (MS), sometimes the initial prescribed treatment is maintained for a long period with clinical stability, low disability, and nonsignificant side effects. We aim to describe demographic and clinical characteristics of patients treated in our MS clinic with the same disease-modifying drug (DMD) lasting for >12 years. From the cohort of 51 patients followed in our MS clinic with relapse-remitting MS who started an DMD between 1996 and 1999, we found a high percentage (51%) of patients who were efficiently treated with the first DMD. These patients were mainly females, with low annualized relapse rate and Multiple Sclerosis Severity Score (MSSS). Our results may be related to the open and multidisciplinary model of our MS clinic organization. Identifying characteristics associated with therapy persistence may be useful in developing strategies to improve therapy effectiveness. International Scholarly Research Network 2012-12-22 /pmc/articles/PMC3539327/ /pubmed/23316389 http://dx.doi.org/10.5402/2012/451457 Text en Copyright © 2012 A. T. Carvalho and M. J. Sá. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Carvalho, Ana Teresa
Sá, Maria José
Switching and Escalating Therapy in Long-Lasting Multiple Sclerosis: Not Always Necessary
title Switching and Escalating Therapy in Long-Lasting Multiple Sclerosis: Not Always Necessary
title_full Switching and Escalating Therapy in Long-Lasting Multiple Sclerosis: Not Always Necessary
title_fullStr Switching and Escalating Therapy in Long-Lasting Multiple Sclerosis: Not Always Necessary
title_full_unstemmed Switching and Escalating Therapy in Long-Lasting Multiple Sclerosis: Not Always Necessary
title_short Switching and Escalating Therapy in Long-Lasting Multiple Sclerosis: Not Always Necessary
title_sort switching and escalating therapy in long-lasting multiple sclerosis: not always necessary
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539327/
https://www.ncbi.nlm.nih.gov/pubmed/23316389
http://dx.doi.org/10.5402/2012/451457
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