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Switching and Escalating Therapy in Long-Lasting Multiple Sclerosis: Not Always Necessary
Although therapy switch is common among patients with multiple sclerosis (MS), sometimes the initial prescribed treatment is maintained for a long period with clinical stability, low disability, and nonsignificant side effects. We aim to describe demographic and clinical characteristics of patients...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scholarly Research Network
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539327/ https://www.ncbi.nlm.nih.gov/pubmed/23316389 http://dx.doi.org/10.5402/2012/451457 |
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author | Carvalho, Ana Teresa Sá, Maria José |
author_facet | Carvalho, Ana Teresa Sá, Maria José |
author_sort | Carvalho, Ana Teresa |
collection | PubMed |
description | Although therapy switch is common among patients with multiple sclerosis (MS), sometimes the initial prescribed treatment is maintained for a long period with clinical stability, low disability, and nonsignificant side effects. We aim to describe demographic and clinical characteristics of patients treated in our MS clinic with the same disease-modifying drug (DMD) lasting for >12 years. From the cohort of 51 patients followed in our MS clinic with relapse-remitting MS who started an DMD between 1996 and 1999, we found a high percentage (51%) of patients who were efficiently treated with the first DMD. These patients were mainly females, with low annualized relapse rate and Multiple Sclerosis Severity Score (MSSS). Our results may be related to the open and multidisciplinary model of our MS clinic organization. Identifying characteristics associated with therapy persistence may be useful in developing strategies to improve therapy effectiveness. |
format | Online Article Text |
id | pubmed-3539327 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Scholarly Research Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-35393272013-01-11 Switching and Escalating Therapy in Long-Lasting Multiple Sclerosis: Not Always Necessary Carvalho, Ana Teresa Sá, Maria José ISRN Neurol Clinical Study Although therapy switch is common among patients with multiple sclerosis (MS), sometimes the initial prescribed treatment is maintained for a long period with clinical stability, low disability, and nonsignificant side effects. We aim to describe demographic and clinical characteristics of patients treated in our MS clinic with the same disease-modifying drug (DMD) lasting for >12 years. From the cohort of 51 patients followed in our MS clinic with relapse-remitting MS who started an DMD between 1996 and 1999, we found a high percentage (51%) of patients who were efficiently treated with the first DMD. These patients were mainly females, with low annualized relapse rate and Multiple Sclerosis Severity Score (MSSS). Our results may be related to the open and multidisciplinary model of our MS clinic organization. Identifying characteristics associated with therapy persistence may be useful in developing strategies to improve therapy effectiveness. International Scholarly Research Network 2012-12-22 /pmc/articles/PMC3539327/ /pubmed/23316389 http://dx.doi.org/10.5402/2012/451457 Text en Copyright © 2012 A. T. Carvalho and M. J. Sá. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Carvalho, Ana Teresa Sá, Maria José Switching and Escalating Therapy in Long-Lasting Multiple Sclerosis: Not Always Necessary |
title | Switching and Escalating Therapy in Long-Lasting Multiple Sclerosis: Not Always Necessary |
title_full | Switching and Escalating Therapy in Long-Lasting Multiple Sclerosis: Not Always Necessary |
title_fullStr | Switching and Escalating Therapy in Long-Lasting Multiple Sclerosis: Not Always Necessary |
title_full_unstemmed | Switching and Escalating Therapy in Long-Lasting Multiple Sclerosis: Not Always Necessary |
title_short | Switching and Escalating Therapy in Long-Lasting Multiple Sclerosis: Not Always Necessary |
title_sort | switching and escalating therapy in long-lasting multiple sclerosis: not always necessary |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539327/ https://www.ncbi.nlm.nih.gov/pubmed/23316389 http://dx.doi.org/10.5402/2012/451457 |
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