Cargando…

Comparison of Infection and Urosepsis Rates of Ciprofloxacin and Ceftriaxone Prophylaxis before Percutaneous Nephrolithotomy: A Prospective and Randomised Study

This study aimed at determining the choice and administration duration of ideal antibiotic prophylaxis before percutaneous nephrolithotomy (PNL) operation, a treatment modality for nephrolithiasis. The study included 90 patients who had no internal problem, yet had a negative urine culture and under...

Descripción completa

Detalles Bibliográficos
Autores principales: Demirtas, Abdullah, Yildirim, Yunus Emre, Sofikerim, Mustafa, Kaya, Esma Gunduz, Akinsal, Emre Can, Tombul, Sevket Tolga, Ekmekcioglu, Oguz, Gulmez, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific World Journal 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539373/
https://www.ncbi.nlm.nih.gov/pubmed/23319889
http://dx.doi.org/10.1100/2012/916381
_version_ 1782255074515353600
author Demirtas, Abdullah
Yildirim, Yunus Emre
Sofikerim, Mustafa
Kaya, Esma Gunduz
Akinsal, Emre Can
Tombul, Sevket Tolga
Ekmekcioglu, Oguz
Gulmez, Ibrahim
author_facet Demirtas, Abdullah
Yildirim, Yunus Emre
Sofikerim, Mustafa
Kaya, Esma Gunduz
Akinsal, Emre Can
Tombul, Sevket Tolga
Ekmekcioglu, Oguz
Gulmez, Ibrahim
author_sort Demirtas, Abdullah
collection PubMed
description This study aimed at determining the choice and administration duration of ideal antibiotic prophylaxis before percutaneous nephrolithotomy (PNL) operation, a treatment modality for nephrolithiasis. The study included 90 patients who had no internal problem, yet had a negative urine culture and underwent a PNL operation. We compared infection rates between ciprofloxacin and ceftriaxone groups and their subgroups. The results showed no statistical difference between ciprofloxacin and ceftriaxone groups in terms of systemic inflammatory response syndrome (SIRS) (CIP(P) = 0.306,  CTX P = 0.334. As a result of this study no statistical difference was observed between ciprofloxacin and ceftriaxone in terms of SIRS. It seems, however, reasonable to choose ceftriaxone, considering antibiotic sensitivity of microorganisms and detection of three cases accepted as urosepsis in the ciprofloxacin group. As there is no difference between short, and long-term prophylactic use of these antibiotics, preference of short-term prophylaxis for patients with no risk of infection will be important to avoid inappropriate antibiotic usage.
format Online
Article
Text
id pubmed-3539373
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher The Scientific World Journal
record_format MEDLINE/PubMed
spelling pubmed-35393732013-01-14 Comparison of Infection and Urosepsis Rates of Ciprofloxacin and Ceftriaxone Prophylaxis before Percutaneous Nephrolithotomy: A Prospective and Randomised Study Demirtas, Abdullah Yildirim, Yunus Emre Sofikerim, Mustafa Kaya, Esma Gunduz Akinsal, Emre Can Tombul, Sevket Tolga Ekmekcioglu, Oguz Gulmez, Ibrahim ScientificWorldJournal Clinical Study This study aimed at determining the choice and administration duration of ideal antibiotic prophylaxis before percutaneous nephrolithotomy (PNL) operation, a treatment modality for nephrolithiasis. The study included 90 patients who had no internal problem, yet had a negative urine culture and underwent a PNL operation. We compared infection rates between ciprofloxacin and ceftriaxone groups and their subgroups. The results showed no statistical difference between ciprofloxacin and ceftriaxone groups in terms of systemic inflammatory response syndrome (SIRS) (CIP(P) = 0.306,  CTX P = 0.334. As a result of this study no statistical difference was observed between ciprofloxacin and ceftriaxone in terms of SIRS. It seems, however, reasonable to choose ceftriaxone, considering antibiotic sensitivity of microorganisms and detection of three cases accepted as urosepsis in the ciprofloxacin group. As there is no difference between short, and long-term prophylactic use of these antibiotics, preference of short-term prophylaxis for patients with no risk of infection will be important to avoid inappropriate antibiotic usage. The Scientific World Journal 2012-12-17 /pmc/articles/PMC3539373/ /pubmed/23319889 http://dx.doi.org/10.1100/2012/916381 Text en Copyright © 2012 Abdullah Demirtas et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Demirtas, Abdullah
Yildirim, Yunus Emre
Sofikerim, Mustafa
Kaya, Esma Gunduz
Akinsal, Emre Can
Tombul, Sevket Tolga
Ekmekcioglu, Oguz
Gulmez, Ibrahim
Comparison of Infection and Urosepsis Rates of Ciprofloxacin and Ceftriaxone Prophylaxis before Percutaneous Nephrolithotomy: A Prospective and Randomised Study
title Comparison of Infection and Urosepsis Rates of Ciprofloxacin and Ceftriaxone Prophylaxis before Percutaneous Nephrolithotomy: A Prospective and Randomised Study
title_full Comparison of Infection and Urosepsis Rates of Ciprofloxacin and Ceftriaxone Prophylaxis before Percutaneous Nephrolithotomy: A Prospective and Randomised Study
title_fullStr Comparison of Infection and Urosepsis Rates of Ciprofloxacin and Ceftriaxone Prophylaxis before Percutaneous Nephrolithotomy: A Prospective and Randomised Study
title_full_unstemmed Comparison of Infection and Urosepsis Rates of Ciprofloxacin and Ceftriaxone Prophylaxis before Percutaneous Nephrolithotomy: A Prospective and Randomised Study
title_short Comparison of Infection and Urosepsis Rates of Ciprofloxacin and Ceftriaxone Prophylaxis before Percutaneous Nephrolithotomy: A Prospective and Randomised Study
title_sort comparison of infection and urosepsis rates of ciprofloxacin and ceftriaxone prophylaxis before percutaneous nephrolithotomy: a prospective and randomised study
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539373/
https://www.ncbi.nlm.nih.gov/pubmed/23319889
http://dx.doi.org/10.1100/2012/916381
work_keys_str_mv AT demirtasabdullah comparisonofinfectionandurosepsisratesofciprofloxacinandceftriaxoneprophylaxisbeforepercutaneousnephrolithotomyaprospectiveandrandomisedstudy
AT yildirimyunusemre comparisonofinfectionandurosepsisratesofciprofloxacinandceftriaxoneprophylaxisbeforepercutaneousnephrolithotomyaprospectiveandrandomisedstudy
AT sofikerimmustafa comparisonofinfectionandurosepsisratesofciprofloxacinandceftriaxoneprophylaxisbeforepercutaneousnephrolithotomyaprospectiveandrandomisedstudy
AT kayaesmagunduz comparisonofinfectionandurosepsisratesofciprofloxacinandceftriaxoneprophylaxisbeforepercutaneousnephrolithotomyaprospectiveandrandomisedstudy
AT akinsalemrecan comparisonofinfectionandurosepsisratesofciprofloxacinandceftriaxoneprophylaxisbeforepercutaneousnephrolithotomyaprospectiveandrandomisedstudy
AT tombulsevkettolga comparisonofinfectionandurosepsisratesofciprofloxacinandceftriaxoneprophylaxisbeforepercutaneousnephrolithotomyaprospectiveandrandomisedstudy
AT ekmekciogluoguz comparisonofinfectionandurosepsisratesofciprofloxacinandceftriaxoneprophylaxisbeforepercutaneousnephrolithotomyaprospectiveandrandomisedstudy
AT gulmezibrahim comparisonofinfectionandurosepsisratesofciprofloxacinandceftriaxoneprophylaxisbeforepercutaneousnephrolithotomyaprospectiveandrandomisedstudy