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Effects of Tobacco Smoking in Pregnancy on Offspring Intelligence at the Age of 5
The aim of the study was to examine the effects of tobacco smoking in pregnancy on children's IQ at the age of 5. A prospective follow-up study was conducted on 1,782 women, and their offspring were sampled from the Danish National Birth Cohort. At 5 years of age, the children were tested with...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539404/ https://www.ncbi.nlm.nih.gov/pubmed/23316364 http://dx.doi.org/10.1155/2012/945196 |
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author | Falgreen Eriksen, Hanne-Lise Kesmodel, Ulrik Schiøler Wimberley, Theresa Underbjerg, Mette Kilburn, Tina Røndrup Mortensen, Erik Lykke |
author_facet | Falgreen Eriksen, Hanne-Lise Kesmodel, Ulrik Schiøler Wimberley, Theresa Underbjerg, Mette Kilburn, Tina Røndrup Mortensen, Erik Lykke |
author_sort | Falgreen Eriksen, Hanne-Lise |
collection | PubMed |
description | The aim of the study was to examine the effects of tobacco smoking in pregnancy on children's IQ at the age of 5. A prospective follow-up study was conducted on 1,782 women, and their offspring were sampled from the Danish National Birth Cohort. At 5 years of age, the children were tested with the Wechsler Preschool and Primary Scale of Intelligence-Revised. Parental education, maternal IQ, maternal alcohol consumption in pregnancy, the sex and age of the child, and tester were considered core confounders, but the full model also controlled for prenatal paternal smoking, maternal age and Bodymass Mass Index, parity, family/home environment, postnatal parental smoking, breast feeding, the child's health status, and indicators for hearing and vision impairments. Unadjusted analyses showed a statistically significant decrement of 4 points on full-scale IQ (FSIQ) associated with smoking 10+ cigarettes per day compared to nonsmoking. After adjustment for potential confounders, no significant effects of prenatal exposure to tobacco smoking were found. Considering the indisputable teratogenic effects of tobacco smoking, these findings should be interpreted with caution. Still, the results may indicate that previous studies that failed to control for important confounders, particularly maternal intelligence, may be subject to substantial residual confounding. |
format | Online Article Text |
id | pubmed-3539404 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35394042013-01-11 Effects of Tobacco Smoking in Pregnancy on Offspring Intelligence at the Age of 5 Falgreen Eriksen, Hanne-Lise Kesmodel, Ulrik Schiøler Wimberley, Theresa Underbjerg, Mette Kilburn, Tina Røndrup Mortensen, Erik Lykke J Pregnancy Research Article The aim of the study was to examine the effects of tobacco smoking in pregnancy on children's IQ at the age of 5. A prospective follow-up study was conducted on 1,782 women, and their offspring were sampled from the Danish National Birth Cohort. At 5 years of age, the children were tested with the Wechsler Preschool and Primary Scale of Intelligence-Revised. Parental education, maternal IQ, maternal alcohol consumption in pregnancy, the sex and age of the child, and tester were considered core confounders, but the full model also controlled for prenatal paternal smoking, maternal age and Bodymass Mass Index, parity, family/home environment, postnatal parental smoking, breast feeding, the child's health status, and indicators for hearing and vision impairments. Unadjusted analyses showed a statistically significant decrement of 4 points on full-scale IQ (FSIQ) associated with smoking 10+ cigarettes per day compared to nonsmoking. After adjustment for potential confounders, no significant effects of prenatal exposure to tobacco smoking were found. Considering the indisputable teratogenic effects of tobacco smoking, these findings should be interpreted with caution. Still, the results may indicate that previous studies that failed to control for important confounders, particularly maternal intelligence, may be subject to substantial residual confounding. Hindawi Publishing Corporation 2012 2012-12-20 /pmc/articles/PMC3539404/ /pubmed/23316364 http://dx.doi.org/10.1155/2012/945196 Text en Copyright © 2012 Hanne-Lise Falgreen Eriksen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Falgreen Eriksen, Hanne-Lise Kesmodel, Ulrik Schiøler Wimberley, Theresa Underbjerg, Mette Kilburn, Tina Røndrup Mortensen, Erik Lykke Effects of Tobacco Smoking in Pregnancy on Offspring Intelligence at the Age of 5 |
title | Effects of Tobacco Smoking in Pregnancy on Offspring Intelligence at the Age of 5 |
title_full | Effects of Tobacco Smoking in Pregnancy on Offspring Intelligence at the Age of 5 |
title_fullStr | Effects of Tobacco Smoking in Pregnancy on Offspring Intelligence at the Age of 5 |
title_full_unstemmed | Effects of Tobacco Smoking in Pregnancy on Offspring Intelligence at the Age of 5 |
title_short | Effects of Tobacco Smoking in Pregnancy on Offspring Intelligence at the Age of 5 |
title_sort | effects of tobacco smoking in pregnancy on offspring intelligence at the age of 5 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539404/ https://www.ncbi.nlm.nih.gov/pubmed/23316364 http://dx.doi.org/10.1155/2012/945196 |
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