SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses

SCRAPPER, which is an F-box protein encoded by FBXL20, regulates the frequency of the miniature excitatory synaptic current through the ubiquitination of Rab3-interacting molecule 1. Here, we recorded the induction of long-term potentiation/depression (LTP/LTD) in CA3-CA1 synapses in E3 ubiquitin li...

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Detalles Bibliográficos
Autores principales: Takagi, Hiroshi, Setou, Mitsutoshi, Ito, Seiji, Yao, Ikuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539422/
https://www.ncbi.nlm.nih.gov/pubmed/23316391
http://dx.doi.org/10.1155/2012/352829
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author Takagi, Hiroshi
Setou, Mitsutoshi
Ito, Seiji
Yao, Ikuko
author_facet Takagi, Hiroshi
Setou, Mitsutoshi
Ito, Seiji
Yao, Ikuko
author_sort Takagi, Hiroshi
collection PubMed
description SCRAPPER, which is an F-box protein encoded by FBXL20, regulates the frequency of the miniature excitatory synaptic current through the ubiquitination of Rab3-interacting molecule 1. Here, we recorded the induction of long-term potentiation/depression (LTP/LTD) in CA3-CA1 synapses in E3 ubiquitin ligase SCRAPPER-deficient hippocampal slices. Compared to wild-type mice, Scrapper-knockout mice exhibited LTDs with smaller magnitudes after induction with low-frequency stimulation and LTPs with larger magnitudes after induction with tetanus stimulation. These findings suggest that SCRAPPER regulates the threshold of bidirectional synaptic plasticity and, therefore, metaplasticity.
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spelling pubmed-35394222013-01-11 SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses Takagi, Hiroshi Setou, Mitsutoshi Ito, Seiji Yao, Ikuko Neural Plast Research Article SCRAPPER, which is an F-box protein encoded by FBXL20, regulates the frequency of the miniature excitatory synaptic current through the ubiquitination of Rab3-interacting molecule 1. Here, we recorded the induction of long-term potentiation/depression (LTP/LTD) in CA3-CA1 synapses in E3 ubiquitin ligase SCRAPPER-deficient hippocampal slices. Compared to wild-type mice, Scrapper-knockout mice exhibited LTDs with smaller magnitudes after induction with low-frequency stimulation and LTPs with larger magnitudes after induction with tetanus stimulation. These findings suggest that SCRAPPER regulates the threshold of bidirectional synaptic plasticity and, therefore, metaplasticity. Hindawi Publishing Corporation 2012 2012-12-20 /pmc/articles/PMC3539422/ /pubmed/23316391 http://dx.doi.org/10.1155/2012/352829 Text en Copyright © 2012 Hiroshi Takagi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Takagi, Hiroshi
Setou, Mitsutoshi
Ito, Seiji
Yao, Ikuko
SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses
title SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses
title_full SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses
title_fullStr SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses
title_full_unstemmed SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses
title_short SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses
title_sort scrapper regulates the thresholds of long-term potentiation/depression, the bidirectional synaptic plasticity in hippocampal ca3-ca1 synapses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539422/
https://www.ncbi.nlm.nih.gov/pubmed/23316391
http://dx.doi.org/10.1155/2012/352829
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