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Endogenous Proliferation after Spinal Cord Injury in Animal Models

Spinal cord injury (SCI) results in motor and sensory deficits, the severity of which depends on the level and extent of the injury. Animal models for SCI research include transection, contusion, and compression mouse models. In this paper we will discuss the endogenous stem cell response to SCI in...

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Detalles Bibliográficos
Autores principales: McDonough, Ashley, Martínez-Cerdeño, Verónica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539424/
https://www.ncbi.nlm.nih.gov/pubmed/23316243
http://dx.doi.org/10.1155/2012/387513
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author McDonough, Ashley
Martínez-Cerdeño, Verónica
author_facet McDonough, Ashley
Martínez-Cerdeño, Verónica
author_sort McDonough, Ashley
collection PubMed
description Spinal cord injury (SCI) results in motor and sensory deficits, the severity of which depends on the level and extent of the injury. Animal models for SCI research include transection, contusion, and compression mouse models. In this paper we will discuss the endogenous stem cell response to SCI in animal models. All SCI animal models experience a similar peak of cell proliferation three days after injury; however, each specific type of injury promotes a specific and distinct stem cell response. For example, the transection model results in a strong and localized initial increase of proliferation, while in contusion and compression models, the initial level of proliferation is lower but encompasses the entire rostrocaudal extent of the spinal cord. All injury types result in an increased ependymal proliferation, but only in contusion and compression models is there a significant level of proliferation in the lateral regions of the spinal cord. Finally, the fate of newly generated cells varies from a mainly oligodendrocyte fate in contusion and compression to a mostly astrocyte fate in the transection model. Here we will discuss the potential of endogenous stem/progenitor cell manipulation as a therapeutic tool to treat SCI.
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spelling pubmed-35394242013-01-11 Endogenous Proliferation after Spinal Cord Injury in Animal Models McDonough, Ashley Martínez-Cerdeño, Verónica Stem Cells Int Review Article Spinal cord injury (SCI) results in motor and sensory deficits, the severity of which depends on the level and extent of the injury. Animal models for SCI research include transection, contusion, and compression mouse models. In this paper we will discuss the endogenous stem cell response to SCI in animal models. All SCI animal models experience a similar peak of cell proliferation three days after injury; however, each specific type of injury promotes a specific and distinct stem cell response. For example, the transection model results in a strong and localized initial increase of proliferation, while in contusion and compression models, the initial level of proliferation is lower but encompasses the entire rostrocaudal extent of the spinal cord. All injury types result in an increased ependymal proliferation, but only in contusion and compression models is there a significant level of proliferation in the lateral regions of the spinal cord. Finally, the fate of newly generated cells varies from a mainly oligodendrocyte fate in contusion and compression to a mostly astrocyte fate in the transection model. Here we will discuss the potential of endogenous stem/progenitor cell manipulation as a therapeutic tool to treat SCI. Hindawi Publishing Corporation 2012 2012-12-20 /pmc/articles/PMC3539424/ /pubmed/23316243 http://dx.doi.org/10.1155/2012/387513 Text en Copyright © 2012 A. McDonough and V. Martínez-Cerdeño. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
McDonough, Ashley
Martínez-Cerdeño, Verónica
Endogenous Proliferation after Spinal Cord Injury in Animal Models
title Endogenous Proliferation after Spinal Cord Injury in Animal Models
title_full Endogenous Proliferation after Spinal Cord Injury in Animal Models
title_fullStr Endogenous Proliferation after Spinal Cord Injury in Animal Models
title_full_unstemmed Endogenous Proliferation after Spinal Cord Injury in Animal Models
title_short Endogenous Proliferation after Spinal Cord Injury in Animal Models
title_sort endogenous proliferation after spinal cord injury in animal models
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539424/
https://www.ncbi.nlm.nih.gov/pubmed/23316243
http://dx.doi.org/10.1155/2012/387513
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