Cargando…
Activated protein C inhalation: A novel therapeutic strategy for acute lung injury
Acute lung injury (ALI) is a critical illness syndrome with a mortality rate of 25–40%. Despite recent advances of our understanding of the pathophysiology of ALI, no pharmacologic therapies have been proven effective. The key pathogenesis of ALI is the activation of the coagulation cascade and impa...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539554/ https://www.ncbi.nlm.nih.gov/pubmed/21629195 http://dx.doi.org/10.12659/MSM.881789 |
_version_ | 1782255111562592256 |
---|---|
author | Bo, Lulong Bian, Jinjun Li, Jinbao Wan, Xiaojian Zhu, Keming Deng, Xiaoming |
author_facet | Bo, Lulong Bian, Jinjun Li, Jinbao Wan, Xiaojian Zhu, Keming Deng, Xiaoming |
author_sort | Bo, Lulong |
collection | PubMed |
description | Acute lung injury (ALI) is a critical illness syndrome with a mortality rate of 25–40%. Despite recent advances of our understanding of the pathophysiology of ALI, no pharmacologic therapies have been proven effective. The key pathogenesis of ALI is the activation of the coagulation cascade and impaired fibrinolysis, resulting in extensive fibrin and hyaline membrane deposition. Activated protein C (APC), an endogenous protein that promotes fibrinolysis and inhibits thrombosis, can modulate the coagulation and inflammation associated with ALI. It is therefore reasonable to suggest that preventing the progression of pulmonary coagulopathy, by restoring normal intraalveolar levels of protein C, will be of therapeutic benefit to patients with ALI. However, a recent clinical trial demonstrated that APC did not improve outcomes from ALI, raising the possibility that the method of APC administration, intravenous infusion or inhalation, may influence the outcomes. In this article we propose the hypothesis that APC inhalation might be a promising and novel choice in the treatment of ALI. |
format | Online Article Text |
id | pubmed-3539554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-35395542013-04-24 Activated protein C inhalation: A novel therapeutic strategy for acute lung injury Bo, Lulong Bian, Jinjun Li, Jinbao Wan, Xiaojian Zhu, Keming Deng, Xiaoming Med Sci Monit Hypothesis Acute lung injury (ALI) is a critical illness syndrome with a mortality rate of 25–40%. Despite recent advances of our understanding of the pathophysiology of ALI, no pharmacologic therapies have been proven effective. The key pathogenesis of ALI is the activation of the coagulation cascade and impaired fibrinolysis, resulting in extensive fibrin and hyaline membrane deposition. Activated protein C (APC), an endogenous protein that promotes fibrinolysis and inhibits thrombosis, can modulate the coagulation and inflammation associated with ALI. It is therefore reasonable to suggest that preventing the progression of pulmonary coagulopathy, by restoring normal intraalveolar levels of protein C, will be of therapeutic benefit to patients with ALI. However, a recent clinical trial demonstrated that APC did not improve outcomes from ALI, raising the possibility that the method of APC administration, intravenous infusion or inhalation, may influence the outcomes. In this article we propose the hypothesis that APC inhalation might be a promising and novel choice in the treatment of ALI. International Scientific Literature, Inc. 2011-06-01 /pmc/articles/PMC3539554/ /pubmed/21629195 http://dx.doi.org/10.12659/MSM.881789 Text en © Med Sci Monit, 2011 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. |
spellingShingle | Hypothesis Bo, Lulong Bian, Jinjun Li, Jinbao Wan, Xiaojian Zhu, Keming Deng, Xiaoming Activated protein C inhalation: A novel therapeutic strategy for acute lung injury |
title | Activated protein C inhalation: A novel therapeutic strategy for acute lung injury |
title_full | Activated protein C inhalation: A novel therapeutic strategy for acute lung injury |
title_fullStr | Activated protein C inhalation: A novel therapeutic strategy for acute lung injury |
title_full_unstemmed | Activated protein C inhalation: A novel therapeutic strategy for acute lung injury |
title_short | Activated protein C inhalation: A novel therapeutic strategy for acute lung injury |
title_sort | activated protein c inhalation: a novel therapeutic strategy for acute lung injury |
topic | Hypothesis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539554/ https://www.ncbi.nlm.nih.gov/pubmed/21629195 http://dx.doi.org/10.12659/MSM.881789 |
work_keys_str_mv | AT bolulong activatedproteincinhalationanoveltherapeuticstrategyforacutelunginjury AT bianjinjun activatedproteincinhalationanoveltherapeuticstrategyforacutelunginjury AT lijinbao activatedproteincinhalationanoveltherapeuticstrategyforacutelunginjury AT wanxiaojian activatedproteincinhalationanoveltherapeuticstrategyforacutelunginjury AT zhukeming activatedproteincinhalationanoveltherapeuticstrategyforacutelunginjury AT dengxiaoming activatedproteincinhalationanoveltherapeuticstrategyforacutelunginjury |