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Activated protein C inhalation: A novel therapeutic strategy for acute lung injury

Acute lung injury (ALI) is a critical illness syndrome with a mortality rate of 25–40%. Despite recent advances of our understanding of the pathophysiology of ALI, no pharmacologic therapies have been proven effective. The key pathogenesis of ALI is the activation of the coagulation cascade and impa...

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Autores principales: Bo, Lulong, Bian, Jinjun, Li, Jinbao, Wan, Xiaojian, Zhu, Keming, Deng, Xiaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539554/
https://www.ncbi.nlm.nih.gov/pubmed/21629195
http://dx.doi.org/10.12659/MSM.881789
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author Bo, Lulong
Bian, Jinjun
Li, Jinbao
Wan, Xiaojian
Zhu, Keming
Deng, Xiaoming
author_facet Bo, Lulong
Bian, Jinjun
Li, Jinbao
Wan, Xiaojian
Zhu, Keming
Deng, Xiaoming
author_sort Bo, Lulong
collection PubMed
description Acute lung injury (ALI) is a critical illness syndrome with a mortality rate of 25–40%. Despite recent advances of our understanding of the pathophysiology of ALI, no pharmacologic therapies have been proven effective. The key pathogenesis of ALI is the activation of the coagulation cascade and impaired fibrinolysis, resulting in extensive fibrin and hyaline membrane deposition. Activated protein C (APC), an endogenous protein that promotes fibrinolysis and inhibits thrombosis, can modulate the coagulation and inflammation associated with ALI. It is therefore reasonable to suggest that preventing the progression of pulmonary coagulopathy, by restoring normal intraalveolar levels of protein C, will be of therapeutic benefit to patients with ALI. However, a recent clinical trial demonstrated that APC did not improve outcomes from ALI, raising the possibility that the method of APC administration, intravenous infusion or inhalation, may influence the outcomes. In this article we propose the hypothesis that APC inhalation might be a promising and novel choice in the treatment of ALI.
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spelling pubmed-35395542013-04-24 Activated protein C inhalation: A novel therapeutic strategy for acute lung injury Bo, Lulong Bian, Jinjun Li, Jinbao Wan, Xiaojian Zhu, Keming Deng, Xiaoming Med Sci Monit Hypothesis Acute lung injury (ALI) is a critical illness syndrome with a mortality rate of 25–40%. Despite recent advances of our understanding of the pathophysiology of ALI, no pharmacologic therapies have been proven effective. The key pathogenesis of ALI is the activation of the coagulation cascade and impaired fibrinolysis, resulting in extensive fibrin and hyaline membrane deposition. Activated protein C (APC), an endogenous protein that promotes fibrinolysis and inhibits thrombosis, can modulate the coagulation and inflammation associated with ALI. It is therefore reasonable to suggest that preventing the progression of pulmonary coagulopathy, by restoring normal intraalveolar levels of protein C, will be of therapeutic benefit to patients with ALI. However, a recent clinical trial demonstrated that APC did not improve outcomes from ALI, raising the possibility that the method of APC administration, intravenous infusion or inhalation, may influence the outcomes. In this article we propose the hypothesis that APC inhalation might be a promising and novel choice in the treatment of ALI. International Scientific Literature, Inc. 2011-06-01 /pmc/articles/PMC3539554/ /pubmed/21629195 http://dx.doi.org/10.12659/MSM.881789 Text en © Med Sci Monit, 2011 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
spellingShingle Hypothesis
Bo, Lulong
Bian, Jinjun
Li, Jinbao
Wan, Xiaojian
Zhu, Keming
Deng, Xiaoming
Activated protein C inhalation: A novel therapeutic strategy for acute lung injury
title Activated protein C inhalation: A novel therapeutic strategy for acute lung injury
title_full Activated protein C inhalation: A novel therapeutic strategy for acute lung injury
title_fullStr Activated protein C inhalation: A novel therapeutic strategy for acute lung injury
title_full_unstemmed Activated protein C inhalation: A novel therapeutic strategy for acute lung injury
title_short Activated protein C inhalation: A novel therapeutic strategy for acute lung injury
title_sort activated protein c inhalation: a novel therapeutic strategy for acute lung injury
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539554/
https://www.ncbi.nlm.nih.gov/pubmed/21629195
http://dx.doi.org/10.12659/MSM.881789
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