Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis

The relationship between acidosis within the tumor microenvironment and radioresistance of hypoxic tumor cells remains unclear. Previously we reported that hypoxia-induced carbonic anhydrases (CA) IX and CAXII constitute a robust intracellular pH (pH(i))-regulating system that confers a survival adv...

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Detalles Bibliográficos
Autores principales: Doyen, Jérome, Parks, Scott K., Marcié, Serge, Pouysségur, Jacques, Chiche, Johanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539669/
https://www.ncbi.nlm.nih.gov/pubmed/23316475
http://dx.doi.org/10.3389/fonc.2012.00199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539669/
https://www.ncbi.nlm.nih.gov/pubmed/23316475
http://dx.doi.org/10.3389/fonc.2012.00199

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