The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses

Interactions between several tumor necrosis factor (TNF)-TNF receptor (TNFR) superfamily members that are expressed by T cells and natural killer (NK) cells and various other cell types modulate immune responses. This review summarizes the current understanding of how the TNF ligand-TNFR interaction...

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Detalles Bibliográficos
Autor principal: Barao, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539674/
https://www.ncbi.nlm.nih.gov/pubmed/23316193
http://dx.doi.org/10.3389/fimmu.2012.00402
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author Barao, Isabel
author_facet Barao, Isabel
author_sort Barao, Isabel
collection PubMed
description Interactions between several tumor necrosis factor (TNF)-TNF receptor (TNFR) superfamily members that are expressed by T cells and natural killer (NK) cells and various other cell types modulate immune responses. This review summarizes the current understanding of how the TNF ligand-TNFR interactions 4-1BBL with 4-1BB, and GITRL with glucocorticoid-induced TNFR-related (GITR) regulate NK cell mediated antitumor responses and discuss its therapeutic implications.
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spelling pubmed-35396742013-01-11 The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses Barao, Isabel Front Immunol Immunology Interactions between several tumor necrosis factor (TNF)-TNF receptor (TNFR) superfamily members that are expressed by T cells and natural killer (NK) cells and various other cell types modulate immune responses. This review summarizes the current understanding of how the TNF ligand-TNFR interactions 4-1BBL with 4-1BB, and GITRL with glucocorticoid-induced TNFR-related (GITR) regulate NK cell mediated antitumor responses and discuss its therapeutic implications. Frontiers Media S.A. 2013-01-04 /pmc/articles/PMC3539674/ /pubmed/23316193 http://dx.doi.org/10.3389/fimmu.2012.00402 Text en Copyright © 2013 Barao. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Immunology
Barao, Isabel
The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses
title The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses
title_full The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses
title_fullStr The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses
title_full_unstemmed The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses
title_short The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses
title_sort tnf receptor-ligands 4-1bb-4-1bbl and gitr-gitrl in nk cell responses
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539674/
https://www.ncbi.nlm.nih.gov/pubmed/23316193
http://dx.doi.org/10.3389/fimmu.2012.00402
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