Cargando…
Germ cell development in the postnatal testis: the key to prevent malignancy in cryptorchidism?
To permit normal postnatal germ cell development, the mammalian testis undergoes a complex, multi-staged process of descent to the scrotum. Failure of any part of this process leads to congenital cryptorchidism, wherein the malpositioned testis finds itself at the wrong temperature after birth, whic...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539691/ https://www.ncbi.nlm.nih.gov/pubmed/23316184 http://dx.doi.org/10.3389/fendo.2012.00176 |
_version_ | 1782255136902479872 |
---|---|
author | Hutson, John M. Li, Ruili Southwell, Bridget R. Petersen, Bodil L. Thorup, Jorgen Cortes, Dina |
author_facet | Hutson, John M. Li, Ruili Southwell, Bridget R. Petersen, Bodil L. Thorup, Jorgen Cortes, Dina |
author_sort | Hutson, John M. |
collection | PubMed |
description | To permit normal postnatal germ cell development, the mammalian testis undergoes a complex, multi-staged process of descent to the scrotum. Failure of any part of this process leads to congenital cryptorchidism, wherein the malpositioned testis finds itself at the wrong temperature after birth, which leads to secondary germ cell loss and later infertility and risk of cancer. Recent studies suggest that neonatal gonocytes transform into the putative spermatogenic stem cells between 3 and 9 months, and this initial postnatal step is deranged in cryptorchid testes. In addition, it is thought the abnormality high temperature may also impair apoptosis of remaining gonocytes, allowing some to persist to become the possible source of carcinoma in situ and malignancy after puberty. The biology of postnatal germ cell development is of intense interest, as it is likely to be the key to the optimal timing for orchidopexy. |
format | Online Article Text |
id | pubmed-3539691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-35396912013-01-11 Germ cell development in the postnatal testis: the key to prevent malignancy in cryptorchidism? Hutson, John M. Li, Ruili Southwell, Bridget R. Petersen, Bodil L. Thorup, Jorgen Cortes, Dina Front Endocrinol (Lausanne) Endocrinology To permit normal postnatal germ cell development, the mammalian testis undergoes a complex, multi-staged process of descent to the scrotum. Failure of any part of this process leads to congenital cryptorchidism, wherein the malpositioned testis finds itself at the wrong temperature after birth, which leads to secondary germ cell loss and later infertility and risk of cancer. Recent studies suggest that neonatal gonocytes transform into the putative spermatogenic stem cells between 3 and 9 months, and this initial postnatal step is deranged in cryptorchid testes. In addition, it is thought the abnormality high temperature may also impair apoptosis of remaining gonocytes, allowing some to persist to become the possible source of carcinoma in situ and malignancy after puberty. The biology of postnatal germ cell development is of intense interest, as it is likely to be the key to the optimal timing for orchidopexy. Frontiers Media S.A. 2013-01-03 /pmc/articles/PMC3539691/ /pubmed/23316184 http://dx.doi.org/10.3389/fendo.2012.00176 Text en Copyright © Hutson, Li, Southwell, Petersen, Thorup and Cortes. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Endocrinology Hutson, John M. Li, Ruili Southwell, Bridget R. Petersen, Bodil L. Thorup, Jorgen Cortes, Dina Germ cell development in the postnatal testis: the key to prevent malignancy in cryptorchidism? |
title | Germ cell development in the postnatal testis: the key to prevent malignancy in cryptorchidism? |
title_full | Germ cell development in the postnatal testis: the key to prevent malignancy in cryptorchidism? |
title_fullStr | Germ cell development in the postnatal testis: the key to prevent malignancy in cryptorchidism? |
title_full_unstemmed | Germ cell development in the postnatal testis: the key to prevent malignancy in cryptorchidism? |
title_short | Germ cell development in the postnatal testis: the key to prevent malignancy in cryptorchidism? |
title_sort | germ cell development in the postnatal testis: the key to prevent malignancy in cryptorchidism? |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539691/ https://www.ncbi.nlm.nih.gov/pubmed/23316184 http://dx.doi.org/10.3389/fendo.2012.00176 |
work_keys_str_mv | AT hutsonjohnm germcelldevelopmentinthepostnataltestisthekeytopreventmalignancyincryptorchidism AT liruili germcelldevelopmentinthepostnataltestisthekeytopreventmalignancyincryptorchidism AT southwellbridgetr germcelldevelopmentinthepostnataltestisthekeytopreventmalignancyincryptorchidism AT petersenbodill germcelldevelopmentinthepostnataltestisthekeytopreventmalignancyincryptorchidism AT thorupjorgen germcelldevelopmentinthepostnataltestisthekeytopreventmalignancyincryptorchidism AT cortesdina germcelldevelopmentinthepostnataltestisthekeytopreventmalignancyincryptorchidism |