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A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons
We present a biophysical approach for the coupling of neural network activity as resulting from proper dipole currents of cortical pyramidal neurons to the electric field in extracellular fluid. Starting from a reduced three-compartment model of a single pyramidal neuron, we derive an observation mo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539751/ https://www.ncbi.nlm.nih.gov/pubmed/23316157 http://dx.doi.org/10.3389/fncom.2012.00100 |
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author | beim Graben, Peter Rodrigues, Serafim |
author_facet | beim Graben, Peter Rodrigues, Serafim |
author_sort | beim Graben, Peter |
collection | PubMed |
description | We present a biophysical approach for the coupling of neural network activity as resulting from proper dipole currents of cortical pyramidal neurons to the electric field in extracellular fluid. Starting from a reduced three-compartment model of a single pyramidal neuron, we derive an observation model for dendritic dipole currents in extracellular space and thereby for the dendritic field potential (DFP) that contributes to the local field potential (LFP) of a neural population. This work aligns and satisfies the widespread dipole assumption that is motivated by the “open-field” configuration of the DFP around cortical pyramidal cells. Our reduced three-compartment scheme allows to derive networks of leaky integrate-and-fire (LIF) models, which facilitates comparison with existing neural network and observation models. In particular, by means of numerical simulations we compare our approach with an ad hoc model by Mazzoni et al. (2008), and conclude that our biophysically motivated approach yields substantial improvement. |
format | Online Article Text |
id | pubmed-3539751 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-35397512013-01-11 A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons beim Graben, Peter Rodrigues, Serafim Front Comput Neurosci Neuroscience We present a biophysical approach for the coupling of neural network activity as resulting from proper dipole currents of cortical pyramidal neurons to the electric field in extracellular fluid. Starting from a reduced three-compartment model of a single pyramidal neuron, we derive an observation model for dendritic dipole currents in extracellular space and thereby for the dendritic field potential (DFP) that contributes to the local field potential (LFP) of a neural population. This work aligns and satisfies the widespread dipole assumption that is motivated by the “open-field” configuration of the DFP around cortical pyramidal cells. Our reduced three-compartment scheme allows to derive networks of leaky integrate-and-fire (LIF) models, which facilitates comparison with existing neural network and observation models. In particular, by means of numerical simulations we compare our approach with an ad hoc model by Mazzoni et al. (2008), and conclude that our biophysically motivated approach yields substantial improvement. Frontiers Media S.A. 2013-01-04 /pmc/articles/PMC3539751/ /pubmed/23316157 http://dx.doi.org/10.3389/fncom.2012.00100 Text en Copyright © 2013 beim Graben and Rodrigues. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Neuroscience beim Graben, Peter Rodrigues, Serafim A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons |
title | A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons |
title_full | A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons |
title_fullStr | A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons |
title_full_unstemmed | A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons |
title_short | A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons |
title_sort | biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539751/ https://www.ncbi.nlm.nih.gov/pubmed/23316157 http://dx.doi.org/10.3389/fncom.2012.00100 |
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