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A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons

We present a biophysical approach for the coupling of neural network activity as resulting from proper dipole currents of cortical pyramidal neurons to the electric field in extracellular fluid. Starting from a reduced three-compartment model of a single pyramidal neuron, we derive an observation mo...

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Detalles Bibliográficos
Autores principales: beim Graben, Peter, Rodrigues, Serafim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539751/
https://www.ncbi.nlm.nih.gov/pubmed/23316157
http://dx.doi.org/10.3389/fncom.2012.00100
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author beim Graben, Peter
Rodrigues, Serafim
author_facet beim Graben, Peter
Rodrigues, Serafim
author_sort beim Graben, Peter
collection PubMed
description We present a biophysical approach for the coupling of neural network activity as resulting from proper dipole currents of cortical pyramidal neurons to the electric field in extracellular fluid. Starting from a reduced three-compartment model of a single pyramidal neuron, we derive an observation model for dendritic dipole currents in extracellular space and thereby for the dendritic field potential (DFP) that contributes to the local field potential (LFP) of a neural population. This work aligns and satisfies the widespread dipole assumption that is motivated by the “open-field” configuration of the DFP around cortical pyramidal cells. Our reduced three-compartment scheme allows to derive networks of leaky integrate-and-fire (LIF) models, which facilitates comparison with existing neural network and observation models. In particular, by means of numerical simulations we compare our approach with an ad hoc model by Mazzoni et al. (2008), and conclude that our biophysically motivated approach yields substantial improvement.
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spelling pubmed-35397512013-01-11 A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons beim Graben, Peter Rodrigues, Serafim Front Comput Neurosci Neuroscience We present a biophysical approach for the coupling of neural network activity as resulting from proper dipole currents of cortical pyramidal neurons to the electric field in extracellular fluid. Starting from a reduced three-compartment model of a single pyramidal neuron, we derive an observation model for dendritic dipole currents in extracellular space and thereby for the dendritic field potential (DFP) that contributes to the local field potential (LFP) of a neural population. This work aligns and satisfies the widespread dipole assumption that is motivated by the “open-field” configuration of the DFP around cortical pyramidal cells. Our reduced three-compartment scheme allows to derive networks of leaky integrate-and-fire (LIF) models, which facilitates comparison with existing neural network and observation models. In particular, by means of numerical simulations we compare our approach with an ad hoc model by Mazzoni et al. (2008), and conclude that our biophysically motivated approach yields substantial improvement. Frontiers Media S.A. 2013-01-04 /pmc/articles/PMC3539751/ /pubmed/23316157 http://dx.doi.org/10.3389/fncom.2012.00100 Text en Copyright © 2013 beim Graben and Rodrigues. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Neuroscience
beim Graben, Peter
Rodrigues, Serafim
A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons
title A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons
title_full A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons
title_fullStr A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons
title_full_unstemmed A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons
title_short A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons
title_sort biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539751/
https://www.ncbi.nlm.nih.gov/pubmed/23316157
http://dx.doi.org/10.3389/fncom.2012.00100
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