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Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder

The dysregulation of the serotonergic system has long been recognized as an important factor underlying the pathophysiology of PTSD. To date, SSRIs have already been established as the firstline pharmacotherapeutic agents for treating acute and chronic PTSD. However, SSRIs largely have several disad...

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Autores principales: Zhang, Li-Ming, Yao, Jia-Zhi, Li, Yang, Li, Kai, Chen, Hong-Xia, Zhang, You-Zhi, Li, Yun-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539772/
https://www.ncbi.nlm.nih.gov/pubmed/23316258
http://dx.doi.org/10.1155/2012/623753
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author Zhang, Li-Ming
Yao, Jia-Zhi
Li, Yang
Li, Kai
Chen, Hong-Xia
Zhang, You-Zhi
Li, Yun-Feng
author_facet Zhang, Li-Ming
Yao, Jia-Zhi
Li, Yang
Li, Kai
Chen, Hong-Xia
Zhang, You-Zhi
Li, Yun-Feng
author_sort Zhang, Li-Ming
collection PubMed
description The dysregulation of the serotonergic system has long been recognized as an important factor underlying the pathophysiology of PTSD. To date, SSRIs have already been established as the firstline pharmacotherapeutic agents for treating acute and chronic PTSD. However, SSRIs largely have several disadvantages which limit their utility. Our previous study has also shown that administration of the total flavonoids, isolated from the extract of Xiaobuxin-Tang (XBXT, mild mind-easing decoction), comprising four Chinese medicines including Haematitum, Flos Inulae, Folium Phyllostachydis Henonis, and Semen Sojae Preparatum, exerted significant antidepressant-like effect in chronically mildly stressed rats, possibly mediated by serotonergic activation. Since the central serotonergic dysfunction is an important and well-known cause mediating the pathophysiology of trauma-related symptoms in PTSD, it is reasonable to predict that flavonoids may exert therapeutic effects on PTSD in animal models. Therefore, the present study aims to examine the effect of flavonoids in alleviating the enhanced anxiety and fear response induced in two PTSD animal models. Ser, an SSRI, was administered as a positive control. Furthermore, the changes of brain monoaminergic neurotransmitters after chronic flavonoids administration have also been assessed in SPS-treated rats.
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spelling pubmed-35397722013-01-11 Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder Zhang, Li-Ming Yao, Jia-Zhi Li, Yang Li, Kai Chen, Hong-Xia Zhang, You-Zhi Li, Yun-Feng Evid Based Complement Alternat Med Research Article The dysregulation of the serotonergic system has long been recognized as an important factor underlying the pathophysiology of PTSD. To date, SSRIs have already been established as the firstline pharmacotherapeutic agents for treating acute and chronic PTSD. However, SSRIs largely have several disadvantages which limit their utility. Our previous study has also shown that administration of the total flavonoids, isolated from the extract of Xiaobuxin-Tang (XBXT, mild mind-easing decoction), comprising four Chinese medicines including Haematitum, Flos Inulae, Folium Phyllostachydis Henonis, and Semen Sojae Preparatum, exerted significant antidepressant-like effect in chronically mildly stressed rats, possibly mediated by serotonergic activation. Since the central serotonergic dysfunction is an important and well-known cause mediating the pathophysiology of trauma-related symptoms in PTSD, it is reasonable to predict that flavonoids may exert therapeutic effects on PTSD in animal models. Therefore, the present study aims to examine the effect of flavonoids in alleviating the enhanced anxiety and fear response induced in two PTSD animal models. Ser, an SSRI, was administered as a positive control. Furthermore, the changes of brain monoaminergic neurotransmitters after chronic flavonoids administration have also been assessed in SPS-treated rats. Hindawi Publishing Corporation 2012 2012-12-13 /pmc/articles/PMC3539772/ /pubmed/23316258 http://dx.doi.org/10.1155/2012/623753 Text en Copyright © 2012 Li-Ming Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Li-Ming
Yao, Jia-Zhi
Li, Yang
Li, Kai
Chen, Hong-Xia
Zhang, You-Zhi
Li, Yun-Feng
Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder
title Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder
title_full Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder
title_fullStr Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder
title_full_unstemmed Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder
title_short Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder
title_sort anxiolytic effects of flavonoids in animal models of posttraumatic stress disorder
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539772/
https://www.ncbi.nlm.nih.gov/pubmed/23316258
http://dx.doi.org/10.1155/2012/623753
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