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Developmental regulation of spatio-temporal patterns of cortical circuit activation

Neural circuits are refined in an experience-dependent manner during early postnatal development. How development modulates the spatio-temporal propagation of activity through cortical circuits is poorly understood. Here we use voltage-sensitive dye imaging (VSD) to show that there are significant c...

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Autores principales: Griffen, Trevor C., Wang, Lang, Fontanini, Alfredo, Maffei, Arianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539829/
https://www.ncbi.nlm.nih.gov/pubmed/23316135
http://dx.doi.org/10.3389/fncel.2012.00065
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author Griffen, Trevor C.
Wang, Lang
Fontanini, Alfredo
Maffei, Arianna
author_facet Griffen, Trevor C.
Wang, Lang
Fontanini, Alfredo
Maffei, Arianna
author_sort Griffen, Trevor C.
collection PubMed
description Neural circuits are refined in an experience-dependent manner during early postnatal development. How development modulates the spatio-temporal propagation of activity through cortical circuits is poorly understood. Here we use voltage-sensitive dye imaging (VSD) to show that there are significant changes in the spatio-temporal patterns of intracortical signals in primary visual cortex (V1) from postnatal day 13 (P13), eye opening, to P28, the peak of the critical period for rodent visual cortical plasticity. Upon direct stimulation of layer 4 (L4), activity spreads to L2/3 and to L5 at all ages. However, while from eye opening to the peak of the critical period, the amplitude and persistence of the voltage signal decrease, peak activation is reached more quickly and the interlaminar gain increases with age. The lateral spread of activation within layers remains unchanged throughout the time window under analysis. These developmental changes in spatio-temporal patterns of intracortical circuit activation are mediated by differences in the contributions of excitatory and inhibitory synaptic components. Our results demonstrate that after eye opening the circuit in V1 is refined through a progression of changes that shape the spatio-temporal patterns of circuit activation. Signals become more efficiently propagated across layers through developmentally regulated changes in interlaminar gain.
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spelling pubmed-35398292013-01-11 Developmental regulation of spatio-temporal patterns of cortical circuit activation Griffen, Trevor C. Wang, Lang Fontanini, Alfredo Maffei, Arianna Front Cell Neurosci Neuroscience Neural circuits are refined in an experience-dependent manner during early postnatal development. How development modulates the spatio-temporal propagation of activity through cortical circuits is poorly understood. Here we use voltage-sensitive dye imaging (VSD) to show that there are significant changes in the spatio-temporal patterns of intracortical signals in primary visual cortex (V1) from postnatal day 13 (P13), eye opening, to P28, the peak of the critical period for rodent visual cortical plasticity. Upon direct stimulation of layer 4 (L4), activity spreads to L2/3 and to L5 at all ages. However, while from eye opening to the peak of the critical period, the amplitude and persistence of the voltage signal decrease, peak activation is reached more quickly and the interlaminar gain increases with age. The lateral spread of activation within layers remains unchanged throughout the time window under analysis. These developmental changes in spatio-temporal patterns of intracortical circuit activation are mediated by differences in the contributions of excitatory and inhibitory synaptic components. Our results demonstrate that after eye opening the circuit in V1 is refined through a progression of changes that shape the spatio-temporal patterns of circuit activation. Signals become more efficiently propagated across layers through developmentally regulated changes in interlaminar gain. Frontiers Media S.A. 2013-01-04 /pmc/articles/PMC3539829/ /pubmed/23316135 http://dx.doi.org/10.3389/fncel.2012.00065 Text en Copyright © 2013 Griffen, Wang, Fontanini and Maffei. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Neuroscience
Griffen, Trevor C.
Wang, Lang
Fontanini, Alfredo
Maffei, Arianna
Developmental regulation of spatio-temporal patterns of cortical circuit activation
title Developmental regulation of spatio-temporal patterns of cortical circuit activation
title_full Developmental regulation of spatio-temporal patterns of cortical circuit activation
title_fullStr Developmental regulation of spatio-temporal patterns of cortical circuit activation
title_full_unstemmed Developmental regulation of spatio-temporal patterns of cortical circuit activation
title_short Developmental regulation of spatio-temporal patterns of cortical circuit activation
title_sort developmental regulation of spatio-temporal patterns of cortical circuit activation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539829/
https://www.ncbi.nlm.nih.gov/pubmed/23316135
http://dx.doi.org/10.3389/fncel.2012.00065
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