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Physiological response of Pichia pastoris GS115 to methanol-induced high level production of the Hepatitis B surface antigen: catabolic adaptation, stress responses, and autophagic processes

BACKGROUND: Pichia pastoris is an established eukaryotic host for the production of recombinant proteins. Most often, protein production is under the control of the strong methanol-inducible aox1 promoter. However, detailed information about the physiological alterations in P. pastoris accompanying...

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Detalles Bibliográficos
Autores principales:	Vanz, Ana Leticia, Lünsdorf, Heinrich, Adnan, Ahmad, Nimtz, Manfred, Gurramkonda, Chandrasekhar, Khanna, Navin, Rinas, Ursula
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539919/ https://www.ncbi.nlm.nih.gov/pubmed/22873405 http://dx.doi.org/10.1186/1475-2859-11-103

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