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Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s active site closure

BACKGROUND: Human farnesyl pyrophosphate synthase (FPPS) controls intracellular levels of farnesyl pyrophosphate, which is essential for various biological processes. Bisphosphonate inhibitors of human FPPS are valuable therapeutics for the treatment of bone-resorption disorders and have also demons...

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Detalles Bibliográficos
Autores principales:	Park, Jaeok, Lin, Yih-Shyan, De Schutter, Joris W, Tsantrizos, Youla S, Berghuis, Albert M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539973/ https://www.ncbi.nlm.nih.gov/pubmed/23234314 http://dx.doi.org/10.1186/1472-6807-12-32

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