Cargando…

Docosahexaenoic acid complexed to human albumin in experimental stroke: neuroprotective efficacy with a wide therapeutic window

BACKGROUND: Docosahexaenoic acid (DHA) complexed to human serum albumin (Alb) is neuroprotective after experimental stroke. Here we tested using lower concentrations of albumin as part of the complex to achieve neuroprotection. We found that lower Alb concentrations extend the therapeutic window of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eady, Tiffany N, Khoutorova, Larissa, Atkins, Kristal D, Bazan, Nicolas G, Belayev, Ludmila
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540001/ https://www.ncbi.nlm.nih.gov/pubmed/22980673 http://dx.doi.org/10.1186/2040-7378-4-19

Ejemplares similares

Docosahexaenoic Acid Therapy of Experimental Ischemic Stroke
por: Belayev, Ludmila, et al.
Publicado: (2010)

Docosahexaenoic Acid Signaling Modulates Cell Survival in Experimental Ischemic Stroke Penumbra and Initiates Long-Term Repair in Young and Aged Rats
por: Eady, Tiffany N., et al.
Publicado: (2012)

Superior Neuroprotective Efficacy of LAU-0901, a Novel Platelet-Activating Factor Antagonist, in Experimental Stroke
por: Belayev, Ludmila, et al.
Publicado: (2011)

Acute Treatment with Docosahexaenoic Acid Complexed to Albumin Reduces Injury after a Permanent Focal Cerebral Ischemia in Rats
por: Eady, Tiffany N., et al.
Publicado: (2013)

Synergistic Neuroprotection by a PAF Antagonist Plus a Docosanoid in Experimental Ischemic Stroke: Dose-Response and Therapeutic Window
por: Reid, Madigan M., et al.
Publicado: (2022)

Docosahexaenoic acid improves behavior and attenuates blood–brain barrier injury induced by focal cerebral ischemia in rats
por: Hong, Sung-Ha, et al.
Publicado: (2015)

Integrated inflammatory signaling landscape response after delivering Elovanoid free-fatty-acid precursors leading to experimental stroke neuroprotection
por: Reid, Madigan M., et al.
Publicado: (2023)

Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke
por: Belayev, Ludmila, et al.
Publicado: (2017)

DHA modulates MANF and TREM2 abundance, enhances neurogenesis, reduces infarct size, and improves neurological function after experimental ischemic stroke
por: Belayev, Ludmila, et al.
Publicado: (2020)

Blocking pro-inflammatory platelet-activating factor receptors and activating cell survival pathways: A novel therapeutic strategy in experimental ischemic stroke
por: Belayev, Ludmila, et al.
Publicado: (2020)

Combined Therapy With Avastin, a PAF Receptor Antagonist and a Lipid Mediator Inhibited Glioblastoma Tumor Growth
por: Cruz Flores, Valerie A., et al.
Publicado: (2021)

NPD1 Plus RvD1 Mediated Ischemic Stroke Penumbra Protection Increases Expression of Pro-homeostatic Microglial and Astrocyte Genes
por: Reid, Madigan M., et al.
Publicado: (2023)

Triglyceride Form of Docosahexaenoic Acid Mediates Neuroprotection in Experimental Parkinsonism
por: Gómez-Soler, Maricel, et al.
Publicado: (2018)

cRel and Wnt5a/Frizzled 5 Receptor-Mediated Inflammatory Regulation Reveal Novel Neuroprotectin D1 Targets for Neuroprotection
por: Calandria, Jorgelina M., et al.
Publicado: (2022)

Elovanoids are a novel class of homeostatic lipid mediators that protect neural cell integrity upon injury
por: Bhattacharjee, Surjyadipta, et al.
Publicado: (2017)

Correction to: cRel and Wnt5a/Frizzled 5 Receptor-Mediated Inflammatory Regulation Reveal Novel Neuroprotectin D1 Targets for Neuroprotection
por: Calandria, Jorgelina M., et al.
Publicado: (2022)

Neuroprotective efficacy and therapeutic window of curcuma oil: in rat embolic stroke model
por: Dohare, Preeti, et al.
Publicado: (2008)

Docosahexaenoic and Arachidonic Acids as Neuroprotective Nutrients throughout the Life Cycle
por: Sambra, Verónica, et al.
Publicado: (2021)

Molecular and Signaling Mechanisms for Docosahexaenoic Acid-Derived Neurodevelopment and Neuroprotection
por: Kim, Hee-Yong, et al.
Publicado: (2022)

Glutamate-releasing BEST1 channel is a new target for neuroprotection against ischemic stroke with wide time window
por: Xiong, Shuai, et al.
Publicado: (2023)

Biomaterials to Neuroprotect the Stroke Brain: A Large Opportunity for Narrow Time Windows
por: González-Nieto, Daniel, et al.
Publicado: (2020)

Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke
por: Matsukawa, Noriyuki, et al.
Publicado: (2009)

Beyond Neuroprotection to Brain Repair: Exploring the Next Frontier in Clinical Neuroscience to Expand the Therapeutic Window for Stroke
por: Ratan, Rajiv R.
Publicado: (2010)

Neuroprotection by cattle encephalon glycoside and ignotin beyond the time window of thrombolysis in ischemic stroke
por: Zhong, Jun, et al.
Publicado: (2020)

Multiprong control of glioblastoma multiforme invasiveness: blockade of pro-inflammatory signaling, anti-angiogenesis, and homeostasis restoration
por: Bazan, Nicolas G., et al.
Publicado: (2021)

Endogenous Signaling by Omega-3 Docosahexaenoic Acid-derived Mediators Sustains Homeostatic Synaptic and Circuitry Integrity
por: Bazan, Nicolas G., et al.
Publicado: (2011)

Defining a mechanistic link between pigment epithelium–derived factor, docosahexaenoic acid, and corneal nerve regeneration
por: Pham, Thang Luong, et al.
Publicado: (2017)

Quantitative Proteomics Reveals Docosahexaenoic Acid-Mediated Neuroprotective Effects in Lipopolysaccharide-Stimulated Microglial Cells
por: Yang, Bo, et al.
Publicado: (2020)

Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging
por: Fernandez, Regina F., et al.
Publicado: (2021)

Melatonin-Based Therapeutics for Neuroprotection in Stroke
por: Shinozuka, Kazutaka, et al.
Publicado: (2013)

Sex-independent neuroprotection with minocycline after experimental thromboembolic stroke
por: Hoda, Md Nasrul, et al.
Publicado: (2011)

Neuroprotective effect of docosahexaenoic acid nanoemulsion on erectile function in a rat model of bilateral cavernous nerve injury
por: Liao, Chun-Hou, et al.
Publicado: (2016)

Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke
por: Clausen, Bettina Hjelm, et al.
Publicado: (2016)

Mechanisms Underlying Neuroprotection by the NSAID Mefenamic Acid in an Experimental Model of Stroke
por: Khansari, Parto S., et al.
Publicado: (2019)

Neuroprotective Phytochemicals in Experimental Ischemic Stroke: Mechanisms and Potential Clinical Applications
por: Xu, Hui, et al.
Publicado: (2021)

Docosahexaenoic acid in diluent for goat semen cryopreservation
por: Souza, Rosiléia Silva, et al.
Publicado: (2021)

Empty Sella Syndrome as a Window Into the Neuroprotective Effects of Prolactin
por: Paul, David A., et al.
Publicado: (2021)

Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival
por: Rice, Dennis S., et al.
Publicado: (2015)

Docosahexaenoic Acid Alleviates Brain Damage by Promoting Mitophagy in Mice with Ischaemic Stroke
por: Sun, Eryi, et al.
Publicado: (2022)

Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection
por: Asatryan, Aram, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_9pfa32781f82nupn5gknp7vq6f