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Environmental Factors Associated with Disease Progression after the First Demyelinating Event: Results from the Multi-Center SET Study
OBJECTIVES: To investigate the associations of environmental MS risk factors with clinical and MRI measures of progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. METHODS: We analyzed 211 CIS patients (age: 28.9±7.8 years) enrolled in the SET study, a mu...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540021/ https://www.ncbi.nlm.nih.gov/pubmed/23320113 http://dx.doi.org/10.1371/journal.pone.0053996 |
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author | Horakova, Dana Zivadinov, Robert Weinstock-Guttman, Bianca Havrdova, Eva Qu, Jun Tamaño-Blanco, Miriam Badgett, Darlene Tyblova, Michaela Bergsland, Niels Hussein, Sara Willis, Laura Krasensky, Jan Vaneckova, Manuela Seidl, Zdenek Lelkova, Petra Dwyer, Michael G. Zhang, Ming Yu, Haoying Duan, Xiaotao Kalincik, Tomas Ramanathan, Murali |
author_facet | Horakova, Dana Zivadinov, Robert Weinstock-Guttman, Bianca Havrdova, Eva Qu, Jun Tamaño-Blanco, Miriam Badgett, Darlene Tyblova, Michaela Bergsland, Niels Hussein, Sara Willis, Laura Krasensky, Jan Vaneckova, Manuela Seidl, Zdenek Lelkova, Petra Dwyer, Michael G. Zhang, Ming Yu, Haoying Duan, Xiaotao Kalincik, Tomas Ramanathan, Murali |
author_sort | Horakova, Dana |
collection | PubMed |
description | OBJECTIVES: To investigate the associations of environmental MS risk factors with clinical and MRI measures of progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. METHODS: We analyzed 211 CIS patients (age: 28.9±7.8 years) enrolled in the SET study, a multi-center study of high-risk CIS patients. Pre-treatment samples were analyzed for IgG antibodies against cytomegalovirus (anti-CMV), Epstein Barr virus (EBV) early nuclear antigen-1 (EBNA-1), viral capsid antigen (VCA), early antigen-diffuse (EA-D), 25 hydroxy-vitamin D3 and cotinine levels and HLA DRB1*1501 status. The inclusion criteria required evaluation within 4 months of the initial demyelinating event, 2 or more brain MRI lesions and the presence of two or more oligoclonal bands in cerebrospinal fluid. All patients were treated with interferon-beta. Clinical and MRI assessments were obtained at baseline, 6, 12, and 24 months. RESULTS: The time to first relapse decreased and the number of relapses increased with anti-CMV IgG positivity. Smoking was associated with increased number and volume of contrast-enhancing lesions (CEL) during the 2-year period. The cumulative number of CEL and T2 lesions during the 2-year period was greater for individuals in the highest quartile of anti-EBV VCA IgG antibodies. The percent loss of brain volume was increased for those in the highest quartile of with anti-EBV VCA IgG antibodies. CONCLUSIONS: Relapses in CIS patients were associated with CMV positivity whereas anti-EBV VCA positivity was associated with progression on MRI measures, including accumulation of CEL and T2 lesions and development of brain atrophy. |
format | Online Article Text |
id | pubmed-3540021 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35400212013-01-14 Environmental Factors Associated with Disease Progression after the First Demyelinating Event: Results from the Multi-Center SET Study Horakova, Dana Zivadinov, Robert Weinstock-Guttman, Bianca Havrdova, Eva Qu, Jun Tamaño-Blanco, Miriam Badgett, Darlene Tyblova, Michaela Bergsland, Niels Hussein, Sara Willis, Laura Krasensky, Jan Vaneckova, Manuela Seidl, Zdenek Lelkova, Petra Dwyer, Michael G. Zhang, Ming Yu, Haoying Duan, Xiaotao Kalincik, Tomas Ramanathan, Murali PLoS One Research Article OBJECTIVES: To investigate the associations of environmental MS risk factors with clinical and MRI measures of progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. METHODS: We analyzed 211 CIS patients (age: 28.9±7.8 years) enrolled in the SET study, a multi-center study of high-risk CIS patients. Pre-treatment samples were analyzed for IgG antibodies against cytomegalovirus (anti-CMV), Epstein Barr virus (EBV) early nuclear antigen-1 (EBNA-1), viral capsid antigen (VCA), early antigen-diffuse (EA-D), 25 hydroxy-vitamin D3 and cotinine levels and HLA DRB1*1501 status. The inclusion criteria required evaluation within 4 months of the initial demyelinating event, 2 or more brain MRI lesions and the presence of two or more oligoclonal bands in cerebrospinal fluid. All patients were treated with interferon-beta. Clinical and MRI assessments were obtained at baseline, 6, 12, and 24 months. RESULTS: The time to first relapse decreased and the number of relapses increased with anti-CMV IgG positivity. Smoking was associated with increased number and volume of contrast-enhancing lesions (CEL) during the 2-year period. The cumulative number of CEL and T2 lesions during the 2-year period was greater for individuals in the highest quartile of anti-EBV VCA IgG antibodies. The percent loss of brain volume was increased for those in the highest quartile of with anti-EBV VCA IgG antibodies. CONCLUSIONS: Relapses in CIS patients were associated with CMV positivity whereas anti-EBV VCA positivity was associated with progression on MRI measures, including accumulation of CEL and T2 lesions and development of brain atrophy. Public Library of Science 2013-01-08 /pmc/articles/PMC3540021/ /pubmed/23320113 http://dx.doi.org/10.1371/journal.pone.0053996 Text en © 2013 Horakova et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Horakova, Dana Zivadinov, Robert Weinstock-Guttman, Bianca Havrdova, Eva Qu, Jun Tamaño-Blanco, Miriam Badgett, Darlene Tyblova, Michaela Bergsland, Niels Hussein, Sara Willis, Laura Krasensky, Jan Vaneckova, Manuela Seidl, Zdenek Lelkova, Petra Dwyer, Michael G. Zhang, Ming Yu, Haoying Duan, Xiaotao Kalincik, Tomas Ramanathan, Murali Environmental Factors Associated with Disease Progression after the First Demyelinating Event: Results from the Multi-Center SET Study |
title | Environmental Factors Associated with Disease Progression after the First Demyelinating Event: Results from the Multi-Center SET Study |
title_full | Environmental Factors Associated with Disease Progression after the First Demyelinating Event: Results from the Multi-Center SET Study |
title_fullStr | Environmental Factors Associated with Disease Progression after the First Demyelinating Event: Results from the Multi-Center SET Study |
title_full_unstemmed | Environmental Factors Associated with Disease Progression after the First Demyelinating Event: Results from the Multi-Center SET Study |
title_short | Environmental Factors Associated with Disease Progression after the First Demyelinating Event: Results from the Multi-Center SET Study |
title_sort | environmental factors associated with disease progression after the first demyelinating event: results from the multi-center set study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540021/ https://www.ncbi.nlm.nih.gov/pubmed/23320113 http://dx.doi.org/10.1371/journal.pone.0053996 |
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