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Engagement of SIRPα Inhibits Growth and Induces Programmed Cell Death in Acute Myeloid Leukemia Cells

BACKGROUND: Recent studies show the importance of interactions between CD47 expressed on acute myeloid leukemia (AML) cells and the inhibitory immunoreceptor, signal regulatory protein-alpha (SIRPα) on macrophages. Although AML cells express SIRPα, its function has not been investigated in these cel...

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Detalles Bibliográficos
Autores principales:	Irandoust, Mahban, Alvarez Zarate, Julian, Hubeek, Isabelle, van Beek, Ellen M., Schornagel, Karin, Broekhuizen, Aart J. F., Akyuz, Mercan, van de Loosdrecht, Arjan A., Delwel, Ruud, Valk, Peter J., Sonneveld, Edwin, Kearns, Pamela, Creutzig, Ursula, Reinhardt, Dirk, de Bont, Eveline S. J. M., Coenen, Eva A., van den Heuvel-Eibrink, Marry M., Zwaan, C. Michel, Kaspers, Gertjan J. L., Cloos, Jacqueline, van den Berg, Timo K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540026/ https://www.ncbi.nlm.nih.gov/pubmed/23320069 http://dx.doi.org/10.1371/journal.pone.0052143

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