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Increases in [(3)H]Muscimol and [(3)H]Flumazenil Binding in the Dorsolateral Prefrontal Cortex in Schizophrenia Are Linked to α4 and γ2S mRNA Levels Respectively

BACKGROUND: GABA(A) receptors (GABA(A)R) are composed of several subunits that determine sensitivity to drugs, synaptic localisation and function. Recent studies suggest that agonists targeting selective GABA(A)R subunits may have therapeutic value against the cognitive impairments observed in schiz...

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Detalles Bibliográficos
Autores principales: Verdurand, Mathieu, Fillman, Stu G., Shannon Weickert, Cynthia, Zavitsanou, Katerina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540049/
https://www.ncbi.nlm.nih.gov/pubmed/23320076
http://dx.doi.org/10.1371/journal.pone.0052724