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Conditional Deletion of the Pten Gene in the Mouse Prostate Induces Prostatic Intraepithelial Neoplasms at Early Ages but a Slow Progression to Prostate Tumors

The PTEN tumor suppressor gene is frequently inactivated in human prostate cancer. Using Osr1 (odd skipped related 1)-Cre mice, we generated a novel conditional Pten knockout mouse strain, Pten(LoxP):Osr1-Cre. Conditional biallelic and monoallelic Pten knockout mice were viable. Deletion of Pten exp...

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Detalles Bibliográficos
Autores principales:	Kwak, Mi Kyung, Johnson, Daniel T., Zhu, Chunfang, Lee, Suk Hyung, Ye, Ding-Wei, Luong, Richard, Sun, Zijie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540073/ https://www.ncbi.nlm.nih.gov/pubmed/23308230 http://dx.doi.org/10.1371/journal.pone.0053476

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