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The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor(+) Innate Lymphoid Cells

Mice lacking the transcription factor T-bet in the innate immune system develop microbiota-dependent colitis. Here, we show that interleukin-17A (IL-17A)-producing IL-7Rα(+) innate lymphoid cells (ILCs) were potent promoters of disease in Tbx21(−/−)Rag2(−/−) ulcerative colitis (TRUC) mice. TNF-α pro...

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Detalles Bibliográficos
Autores principales:	Powell, Nick, Walker, Alan W., Stolarczyk, Emilie, Canavan, James B., Gökmen, M. Refik, Marks, Ellen, Jackson, Ian, Hashim, Ahmed, Curtis, Michael A., Jenner, Richard G., Howard, Jane K., Parkhill, Julian, MacDonald, Thomas T., Lord, Graham M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540260/ https://www.ncbi.nlm.nih.gov/pubmed/23063332 http://dx.doi.org/10.1016/j.immuni.2012.09.008

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