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Exofocal Anterograde Transsynaptic Neuronal Death in the Globus Pallidus: Two Case Reports

BACKGROUND: Exofocal neuronal death in the substantia nigra (SN) is a well-known form of anterograde transsynaptic cell death. Exofocal neuronal death could theoretically also occur in the globus pallidus (GP) after striatal injury. CASE REPORT: Case 1. A 70-year-old woman visited the emergency room...

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Autores principales: Koo, Min Woo, Kim, Yue Kyung, Ku, Kyung Mo, Park, Won Wha, Minn, Yang Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neurological Association 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540292/
https://www.ncbi.nlm.nih.gov/pubmed/23323141
http://dx.doi.org/10.3988/jcn.2012.8.4.308
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author Koo, Min Woo
Kim, Yue Kyung
Ku, Kyung Mo
Park, Won Wha
Minn, Yang Ki
author_facet Koo, Min Woo
Kim, Yue Kyung
Ku, Kyung Mo
Park, Won Wha
Minn, Yang Ki
author_sort Koo, Min Woo
collection PubMed
description BACKGROUND: Exofocal neuronal death in the substantia nigra (SN) is a well-known form of anterograde transsynaptic cell death. Exofocal neuronal death could theoretically also occur in the globus pallidus (GP) after striatal injury. CASE REPORT: Case 1. A 70-year-old woman visited the emergency room because of decreased mentality. On admission, blood-gas analysis indicated that her oxygen tension was 69.1 mm Hg. The caudate nucleus, putamen, and temporooccipital cortex on both sides of the brain exhibited high-intensity diffusion-weighted magnetic resonance imaging (MRI) signals. At 10 days after admission, new high-intensity signals had developed in the SN and GP on both sides. Case 2. A 48-year-old man visited the emergency room because of right-sided weakness. Lesions were noted in the left caudate nucleus and putamen. At 4 days after admission, newly developed high-intensity MRI signals were observed in the left SN and GP. CONCLUSIONS: Exofocal neuronal death can occur in the GP as well as in the SN; these findings need to be clearly distinguished from those of recurrent ischemic injuries, such as recurrent stroke.
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spelling pubmed-35402922013-01-15 Exofocal Anterograde Transsynaptic Neuronal Death in the Globus Pallidus: Two Case Reports Koo, Min Woo Kim, Yue Kyung Ku, Kyung Mo Park, Won Wha Minn, Yang Ki J Clin Neurol Case Report BACKGROUND: Exofocal neuronal death in the substantia nigra (SN) is a well-known form of anterograde transsynaptic cell death. Exofocal neuronal death could theoretically also occur in the globus pallidus (GP) after striatal injury. CASE REPORT: Case 1. A 70-year-old woman visited the emergency room because of decreased mentality. On admission, blood-gas analysis indicated that her oxygen tension was 69.1 mm Hg. The caudate nucleus, putamen, and temporooccipital cortex on both sides of the brain exhibited high-intensity diffusion-weighted magnetic resonance imaging (MRI) signals. At 10 days after admission, new high-intensity signals had developed in the SN and GP on both sides. Case 2. A 48-year-old man visited the emergency room because of right-sided weakness. Lesions were noted in the left caudate nucleus and putamen. At 4 days after admission, newly developed high-intensity MRI signals were observed in the left SN and GP. CONCLUSIONS: Exofocal neuronal death can occur in the GP as well as in the SN; these findings need to be clearly distinguished from those of recurrent ischemic injuries, such as recurrent stroke. Korean Neurological Association 2012-12 2012-12-21 /pmc/articles/PMC3540292/ /pubmed/23323141 http://dx.doi.org/10.3988/jcn.2012.8.4.308 Text en Copyright © 2012 Korean Neurological Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Koo, Min Woo
Kim, Yue Kyung
Ku, Kyung Mo
Park, Won Wha
Minn, Yang Ki
Exofocal Anterograde Transsynaptic Neuronal Death in the Globus Pallidus: Two Case Reports
title Exofocal Anterograde Transsynaptic Neuronal Death in the Globus Pallidus: Two Case Reports
title_full Exofocal Anterograde Transsynaptic Neuronal Death in the Globus Pallidus: Two Case Reports
title_fullStr Exofocal Anterograde Transsynaptic Neuronal Death in the Globus Pallidus: Two Case Reports
title_full_unstemmed Exofocal Anterograde Transsynaptic Neuronal Death in the Globus Pallidus: Two Case Reports
title_short Exofocal Anterograde Transsynaptic Neuronal Death in the Globus Pallidus: Two Case Reports
title_sort exofocal anterograde transsynaptic neuronal death in the globus pallidus: two case reports
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540292/
https://www.ncbi.nlm.nih.gov/pubmed/23323141
http://dx.doi.org/10.3988/jcn.2012.8.4.308
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